Role of cardiac dyssynchrony and resynchronization therapy in functional mitral regurgitation.
Functional mitral regurgitation (FMR) is a common complication of left ventricle (LV) dysfunction and remodelling. Recently, it has been recognized as an independent prognostic factor in both ischaemic and non-ischaemic LV dysfunctions. In this review article, we discuss the mechanisms through which...
| Publicado en: | European Heart Journal - Cardiovascular Imaging Vol. 17; no. 5; pp. 471 - 481 |
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| Formato: | algorithm diagnostic images review tables/charts Journal Article |
| Publicado: |
Oxford University Press / USA
May2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=114870891&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 114870891 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20472404 BMSM jtl: European Heart Journal - Cardiovascular Imaging issn: 20472404 maglogo: N pubinfo: dt: May2016 vid: 17 iid: 5 pid: 622 pub: Oxford University Press / USA artinfo: ui: 114870891 114870891 114870891 10.1093/ehjci/jev352 114870891 ppf: 471 ppct: 10 formats: tig: atl: Role of cardiac dyssynchrony and resynchronization therapy in functional mitral regurgitation. aug: sug: subj: Cardiac Resynchronization Therapy Mitral Valve Insufficiency Computer Terminals Heart Failure Coronary Arteriosclerosis ab: Functional mitral regurgitation (FMR) is a common complication of left ventricle (LV) dysfunction and remodelling. Recently, it has been recognized as an independent prognostic factor in both ischaemic and non-ischaemic LV dysfunctions. In this review article, we discuss the mechanisms through which cardiac dyssynchrony is involved in FMR pathophysiologic cascade and how cardiac resynchronization therapy (CRT) can have therapeutic effects on FMR by reverting specific dyssynchrony pathways. We analyse recent clinical trials focusing on CRT impact on FMR in 'real-world' patients, the limits and future perspectives that could eventually generate new predictors of CRT response in terms of FMR reduction. Finally, we propose a practical diagnostic and therapeutic strategy for the management of symptomatic patients with severe LV dysfunction and concomitant 'prognostic' FMR. pubtype: Academic Journal doctype: algorithm diagnostic images review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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