Urease inhibitory profile of extracts and chemical constituents of Pistacia atlantica ssp. cabulica Stocks.
The current study was designed to evaluate the urease inhibitory profile of extract and fractions ofPistacia atlanticassp. cabulica Stocks followed by bioactivity-guided isolated compounds. The crude extract was found significantly active with urease inhibitor (95.40% at 0.2 mg/mL) with IC50values o...
| Publicado en: | Natural Product Research Vol. 30; no. 12; pp. 1411 - 1417 |
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| Autores principales: | , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Taylor & Francis Ltd
Jun2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=115011141&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 115011141 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14786419 RFT jtl: Natural Product Research issn: 14786419 maglogo: Y pubinfo: dt: Jun2016 vid: 30 iid: 12 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 115011141 10.1080/14786419.2015.1062378 115011141 ppf: 1411 ppct: 6 formats: tig: atl: Urease inhibitory profile of extracts and chemical constituents of Pistacia atlantica ssp. cabulica Stocks. aug: au: Uddin, Ghias Ismail Rauf, Abdur Raza, Muslim Khan, Haroon Nasruddin Khan, Majid Farooq, Umar Khan, Ajmal Arifullah affil: Institute of Chemical Sciences, Centre for Phytomedicine and Medicinal Organic Chemistry, University of Peshawar, Peshawar, Pakistan sug: ab: The current study was designed to evaluate the urease inhibitory profile of extract and fractions ofPistacia atlanticassp. cabulica Stocks followed by bioactivity-guided isolated compounds. The crude extract was found significantly active with urease inhibitor (95.40% at 0.2 mg/mL) with IC50values of 32.0 ± 0.28 μg/mL. Upon fractionation, ethyl acetate fraction displayed 100% urease inhibition with IC50values of 19.9 ± 0.51 μg/mL at 0.2 mg/mL. However,n-hexane and chloroform fractions exhibited insignificant urease inhibition. Similarly, the isolated compound, transilitin (1) and dihydro luteolin (2) demonstrated marked urease attenuation with 95 and 98% respectively, at 0.15 mg/mL. Both the isolated compounds showed marked potency with IC50values of 8.54 ± 0.54 and 9.58 ± 2.22 μg/mL, respectively. In short, both the extract and fractions and isolated compounds showed marked urease inhibition and thus a useful natural source of urease inhibition. Graphical abstract showing the imagePistacia atlantica, chemical structure of isolated compounds and urease enzyme. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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