Dietary Vitamin A and Visceral Adiposity: A Modulating Role of the Retinol-Binding Protein 4 Gene.
Background/aims: Visceral fat (VF) compared with subcutaneous fat (SF) is more closely associated with cardiometabolic disease. Dietary vitamin A (retinol) may reduce adiposity through its effects on adipogenesis differentially in VF and SF, and this effect may be modulated by retinol-binding protei...
| Publicado en: | Journal of Nutrigenetics & Nutrigenomics Vol. 8; no. 4/6; pp. 164 - 174 |
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| Autores principales: | , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Karger AG
Apr2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=115073057&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 115073057 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16616499 39R8 jtl: Journal of Nutrigenetics & Nutrigenomics issn: 16616499 maglogo: N pubinfo: dt: Apr2016 vid: 8 iid: 4/6 pid: 2485 pub: Karger AG artinfo: ui: 115073057 115073057 NLM26667887 115073057 10.1159/000442090 NLM26667887 115073057 ppf: 164 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Dietary Vitamin A and Visceral Adiposity: A Modulating Role of the Retinol-Binding Protein 4 Gene. aug: au: Goodwin, Katie abrahamowicz, Michal Leonard, Gabriel Perron, Michel Richer, Louis Veillette, Suzanne Gaudet, Daniel Paus, Tomas Pausova, Zdenka affil: Departments of Physiology and Nutritional Sciences, The Hospital for Sick Children sug: subj: Carrier Proteins Vitamin A Administration and Dosage Adipose Tissue Distribution Eating Adipose Tissue Metabolism Child Obesity Polymorphism, Genetic Female Male Adolescence Pediatric Obesity Cross Sectional Studies Genetic Techniques Human Child: 6-12 years Adolescent: 13-18 years Female Male ab: Background/aims: Visceral fat (VF) compared with subcutaneous fat (SF) is more closely associated with cardiometabolic disease. Dietary vitamin A (retinol) may reduce adiposity through its effects on adipogenesis differentially in VF and SF, and this effect may be modulated by retinol-binding protein-4 (RBP4). We investigated whether intake of vitamin A is associated with either VF or SF, and whether this association is moderated by the RBP4 genotype (rs10882272, C/T) previously associated with circulating retinol levels.Methods: This was a cross-sectional association study in a sample of 947 adolescents from a French-Canadian founder population. VF and SF were quantified with magnetic resonance imaging, and vitamin A intake was assessed with a 24-hour food recall. All participants were genotyped to determine their RBP4 variant.Results: Dietary intake of vitamin A was negatively associated with VF; however, it was not associated with SF. These relationships were independent of age, sex, height and energy intake, and were modulated by the RBP4 variant. The T allele promoted adiposity-reducing effects of vitamin A in VF and adiposity-enhancing effects in SF, while the C allele had adiposity-reducing effects in both VF and SF.Conclusions: Dietary vitamin A may reduce abdominal adiposity and promote visceral to subcutaneous body fat redistribution during adolescence in an RBP4-dependent manner. These observational findings provide the basis for future interventional studies, which together with genetic information may inject further causality in the association between dietary vitamin A intake and abdominal adiposity. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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