Amyloid in biopsies of the gastrointestinal tract-a retrospective observational study on 542 patients.
In this retrospective observational study, we investigated the histopathological and demographic characteristics of amyloid in gastrointestinal biopsies. From the Amyloid Registry Kiel, we retrieved all cases with amyloid in biopsies of the stomach, duodenum, small intestine, large intestine, and re...
| Published in: | Virchows Archiv: European Journal of Pathology Vol. 468; no. 5; pp. 569 - 578 |
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| Main Authors: | , , , , , |
| Format: | pictorial research tables/charts Journal Article |
| Published: |
Springer Nature
May2016
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=115132262&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 115132262 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09456317 O1Z jtl: Virchows Archiv: European Journal of Pathology issn: 09456317 maglogo: N pubinfo: dt: May2016 vid: 468 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 115132262 115132262 NLM26915034 115132262 10.1007/s00428-016-1916-y NLM26915034 PMC4856726 115132262 ppf: 569 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Amyloid in biopsies of the gastrointestinal tract-a retrospective observational study on 542 patients. aug: au: Freudenthaler, Sophie Hegenbart, Ute Schönland, Stefan Behrens, Hans-Michael Krüger, Sandra Röcken, Christoph affil: Department of Pathology, Christian-Albrechts-University, Arnold-Heller-Str. 3, Haus 14 24105 Kiel Germany sug: subj: Amyloidosis Pathology Amyloidosis Epidemiology Gastrointestinal System Metabolism Gastrointestinal System Pathology Aged Female Male Immunohistochemistry Methods Proteins Metabolism Aged, 80 and Over Biopsy Retrospective Design Prevalence Adolescence Young Adult Middle Age Adult Human Aged: 65+ years Aged, 80 & over Adolescent: 13-18 years Middle Aged: 45-64 years Adult: 19-44 years Female Male ab: In this retrospective observational study, we investigated the histopathological and demographic characteristics of amyloid in gastrointestinal biopsies. From the Amyloid Registry Kiel, we retrieved all cases with amyloid in biopsies of the stomach, duodenum, small intestine, large intestine, and rectum submitted for tertiary referral between January 2003 and April 2013. Amyloid was identified by Congo red staining in combination with polarization microscopy and classified by immunohistochemistry. The TTR-genotype was assessed in 56 patients. Amyloid type was correlated with demographic patient characteristics. Six hundred sixty-three biopsies from 542 patients were retrieved. Amyloid was found in each biopsy as vascular and/or interstitial amyloid deposits. Biopsies were obtained from the colon [254 biopsies (38.3 %)], stomach, [153 (23.1 %)], rectum [112 (16.9 %)], duodenum [105 (15.8 %)], and jejunum/ileum [39 (5.9 %)]. ALλ amyloid was found in 286 (52.8 %), ATTR in 88 (16.2 %), ALκ in 74 (13.7 %), AA in 58 (10.7 %), and ApoAI amyloid in 4 (0.7 %) patients. The remaining 21 cases were ALys amyloid in 4 (0.7 %), AL n.o.s. in 14 (2.6 %), and mixed type amyloidosis in 3 (0.6 %). The amyloid of 11 (2.0 %) cases remained unclassified. The median age of the patients was 68 years. Men [332 (61.7 %)] were significantly more prevalent than women [206 (38.3 %); p < 0.001]. TTR mutations were found in 24 % of the patients with ATTR amyloidosis. The median age, the histoanatomical distribution (proximal to distal; mucosal to submucosal), and the deposition pattern (vascular/interstitial) varied between different amyloid types. Amyloid in gastrointestinal biopsies mainly affects male elderly patients and shows amyloid-type-specific demographic patient characteristics. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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