Daily Optical Coherence Tomography Examinations after First Antivascular Endothelial Growth Factor Injections: An Interventional Case Series.
Purpose. To evaluate daily spectral-domain optical coherence tomography (SD-OCT) changes in naive-treatment patients with diagnosis of exudative age-related macular degeneration (AMD) treated with intravitreous bevacizumab (1.25 mg), during a 30-day follow-up period. Methods. In prospective, interve...
| Publicado en: | Journal of Ophthalmology pp. 1 - 7 |
|---|---|
| Autores principales: | , , , , , , |
| Formato: | diagnostic images pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
5/5/2016
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=115152374&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 115152374 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 2090004X 9038 jtl: Journal of Ophthalmology issn: 2090004X maglogo: N pubinfo: dt: 5/5/2016 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 115152374 115152374 115152374 10.1155/2016/6971831 115152374 ppf: 1 ppct: 6 formats: tig: atl: Daily Optical Coherence Tomography Examinations after First Antivascular Endothelial Growth Factor Injections: An Interventional Case Series. aug: au: Novais, Eduardo A. Badaró, Emmerson Hirai, Flavio E. Jorge, Felipe Abdo Leal, Paula Farah, Michel Eid Rodrigues, Eduardo B. affil: Department of Ophthalmology, Federal University of São Paulo, 04023-062 São Paulo, SP, Brazil sug: subj: Endothelial Growth Factors Tomography, Optical Coherence Macular Degeneration Computer Terminals Bevacizumab Prospective Studies Human Descriptive Statistics Injections ab: Purpose. To evaluate daily spectral-domain optical coherence tomography (SD-OCT) changes in naive-treatment patients with diagnosis of exudative age-related macular degeneration (AMD) treated with intravitreous bevacizumab (1.25 mg), during a 30-day follow-up period. Methods. In prospective, interventional study, SD-OCT was performed daily for 30 days after the first intravitreal injection. The baseline, initial-decrease, minimal, and final central retinal thicknesses (CRTs) were assessed. Results. Nine eyes of nine patients with neovascular AMD were enrolled. The mean baseline CRT was 625.3±182.5 μm, and the mean final CRT was 383.4±163.0 μm (mean difference, 206.1±167.6 μm), a difference that reached significance (P=0.006). After the first injection, the initial decrease in the CRT was seen as an average of one day after injection (mean CRT, 503.6±189.10 μm; P=0.0431). The speed of the reduction in the CRT tended to decrease by day 17. The mean CRT was 336.5±105.44 μm and the mean minimal CRT on day 30 was 320.75±96.38 μm. Conclusion. The CRT decreased early after the first injection. We observed a tendency for reductions in the speed with which the CRT decreased by day 17 after the first injection, which may affect retreatment regime. pubtype: Academic Journal doctype: diagnostic images pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|