Feasibility of a three-step magnetic resonance imaging approach for the assessment of hepatic steatosis in an asymptomatic study population.
Objectives: To determine the feasibility of a multi-step magnetic resonance imaging (MRI) approach for comprehensive assessment of hepatic steatosis defined as liver fat content of ≥5 % in an asymptomatic population.Methods: The study was approved by the institutional review board and written inform...
| Publicado en: | European Radiology Vol. 26; no. 6; pp. 1895 - 1905 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jun2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=115269361&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 115269361 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Jun2016 vid: 26 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 115269361 115269361 NLM26340812 115269361 10.1007/s00330-015-3966-y NLM26340812 115269361 ppf: 1895 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Feasibility of a three-step magnetic resonance imaging approach for the assessment of hepatic steatosis in an asymptomatic study population. aug: au: Hetterich, Holger Bayerl, Christian Peters, Annette Heier, Margit Linkohr, Birgit Meisinger, Christa Auweter, Sigrid Kannengießer, Stephan Kramer, Harald Ertl-Wagner, Birgit Bamberg, Fabian Kannengießer, Stephan A R affil: Institute of Clinical Radiology, Ludwig-Maximilian University Hospital, Marchioninistraße 15 81377 Munich Germany sug: subj: Liver Fatty Liver Diagnosis Magnetic Resonance Imaging Methods Reproducibility of Results Female Adult Male Disease Attributes Middle Age Pilot Studies Aged Prospective Studies Human Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Female Male ab: Objectives: To determine the feasibility of a multi-step magnetic resonance imaging (MRI) approach for comprehensive assessment of hepatic steatosis defined as liver fat content of ≥5 % in an asymptomatic population.Methods: The study was approved by the institutional review board and written informed consent of all participants was obtained. Participants of a population-based study cohort underwent a three-step 3-T MRI-based assessment of liver fat. A dual-echo Dixon sequence was performed to identify subjects with hepatic steatosis, followed by a multi-echo Dixon sequence with proton density fat fraction estimation. Finally, single-voxel T2-corrected multi-echo spectroscopy was performed.Results: A total of 215 participants completed the MRI protocol (56.3 % male, average age 57.2 ± 9.4 years). The prevalence of hepatic steatosis was 55 %. Mean liver proton density fat fraction was 9.2 ± 8.5 % by multi-echo Dixon and 9.3 ± 8.6 % by multi-echo spectroscopy (p = 0.51). Dual-echo Dixon overestimated liver fat fraction by 1.4 ± 2.0 % (p < 0.0001). All measurements showed excellent correlations (r ≥ 0.9, p < 0.001). Dual-echo Dixon was highly sensitive for the detection of hepatic steatosis (sensitivity 0.97, NPV 0.96) with good specificity and PPV (0.75 and 0.81, respectively).Conclusions: A multi-step MRI approach may enable rapid and accurate identification of subjects with hepatic steatosis in an asymptomatic population.Key Points: • Dual-echo Dixon can rapidly and reliably exclude hepatic steatosis without complex post-processing. • Multi-echo Dixon and multi-echo spectroscopy yield similar results regarding hepatic fat quantification. • Each sequence can be performed in one breath-hold. • These sequences can be implemented in routine abdominal MRI protocols. • Thus hepatic fat can be evaluated without relevant increase in scan time. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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