Image quality of Zr-89 PET imaging in the Siemens microPET Focus 220 preclinical scanner.
Purpose: Zr-89 positron emission tomography (PET) is a valuable tool for understanding the biodistribution and pharmacokinetics of antibody-based therapeutics. We compared the image quality of Zr-89 PET and F-18 PET in the Siemens microPET Focus 220 preclinical scanner using different reconstruction...
| Publicado en: | Molecular Imaging & Biology Vol. 18; no. 3; pp. 377 - 386 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | diagnostic images equations & formulas research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jun2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=115398032&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 115398032 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15361632 KJU jtl: Molecular Imaging & Biology issn: 15361632 maglogo: N pubinfo: dt: Jun2016 vid: 18 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 115398032 115398032 NLM26493052 115398032 10.1007/s11307-015-0903-z NLM26493052 115398032 ppf: 377 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Image quality of Zr-89 PET imaging in the Siemens microPET Focus 220 preclinical scanner. aug: au: Bradshaw, Tyler Voorbach, Martin Reuter, David Giamis, Anthony Mudd, Sarah Beaver, John Bradshaw, Tyler J Voorbach, Martin J Reuter, David R Giamis, Anthony M Mudd, Sarah R Beaver, John D affil: Department of Medical Physics, University of Wisconsin, 1111 Highland Ave Rm 1005 Madison 53705 USA sug: subj: Metals Tomography, Emission-Computed Equipment and Supplies Image Processing, Computer Assisted Standards Tomography, Emission-Computed Standards Algorithms Animal Studies Phantoms, Imaging Primates Radioisotopes ab: Purpose: Zr-89 positron emission tomography (PET) is a valuable tool for understanding the biodistribution and pharmacokinetics of antibody-based therapeutics. We compared the image quality of Zr-89 PET and F-18 PET in the Siemens microPET Focus 220 preclinical scanner using different reconstruction methods.Procedures: Image quality metrics were measured in various Zr-89 and F-18 PET phantoms, including the NEMA NU 4-2008 image quality phantom. Images were reconstructed using various algorithms.Results: Zr-89 PET had greater image noise, inferior spatial resolution, and greater spillover than F-18 PET, but comparable recovery coefficients for cylinders of various diameters. Of the reconstruction methods, OSEM3D resulted in the lowest noise, highest recovery coefficients, best spatial resolution, but also the greatest spillover. Scatter correction results were found to be sensitive to varying object sizes.Conclusions: Zr-89 PET image quality was inferior to that of F-18, and no single reconstruction method was superior in all aspects of image quality. pubtype: Academic Journal doctype: diagnostic images equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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