Cryptococcus tetragattii as a major cause of cryptococcal meningitis among HIV-infected individuals in Harare, Zimbabwe.
Objectives: HIV-associated cryptococcal meningitis is commonly caused by Cryptococcus neoformans, whilst infections with Cryptococcus gattii sensu lato are historically rare. Despite available studies, little is known about the occurrence of C. gattii sensu lato infections among HIV-infected individ...
| Publicado en: | Journal of Infection Vol. 72; no. 6; pp. 745 - 753 |
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| Autores principales: | , , , |
| Formato: | research Journal Article |
| Publicado: |
W B Saunders
Jun2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=115437317&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 115437317 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01634453 8IL jtl: Journal of Infection issn: 01634453 maglogo: N pubinfo: dt: Jun2016 vid: 72 iid: 6 pid: 1351 pub: W B Saunders place: Philadelphia, Pennsylvania artinfo: ui: 115437317 115437317 NLM27038502 115437317 10.1016/j.jinf.2016.02.018 NLM27038502 115437317 ppf: 745 ppct: 8 formats: tig: atl: Cryptococcus tetragattii as a major cause of cryptococcal meningitis among HIV-infected individuals in Harare, Zimbabwe. aug: au: Nyazika, Tinashe K. Hagen, Ferry Meis, Jacques F. Robertson, Valerie J. affil: Department of Chemical Pathology, College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe sug: subj: Meningitis, Cryptococcal Microbiology Cryptococcus AIDS-Related Opportunistic Infections Microbiology Sequence Analysis Mycological Typing Techniques Female DNA Hospital Mortality Prevalence Male Cryptococcosis Epidemiology Cryptococcosis Microbiology Cerebrospinal Fluid Microbiology Prospective Studies Meningitis, Cryptococcal Epidemiology Genotype Middle Age Adult Zimbabwe Funding Source Human Middle Aged: 45-64 years Adult: 19-44 years Female Male ab: Objectives: HIV-associated cryptococcal meningitis is commonly caused by Cryptococcus neoformans, whilst infections with Cryptococcus gattii sensu lato are historically rare. Despite available studies, little is known about the occurrence of C. gattii sensu lato infections among HIV-infected individuals in Zimbabwe.Methods: In a prospective cohort, we investigated the prevalence of C. gattii sensu lato meningitis among HIV-infected patients (n = 74) in Harare, Zimbabwe.Results: Of the 66/74 isolates confirmed by molecular characterization, 16.7% (11/66) were found to be C. gattii sensu lato and 83.3% (55/66) C. neoformans sensu stricto. From one patient two phenotypically different C. gattii sensu lato colonies were cultured. The majority (n = 9/12; 75%) of the C. gattii sensu lato isolates were Cryptococcus tetragattii (AFLP7/VGIV), which has been an infrequently reported pathogen. In-hospital mortality associated with C. gattii sensu lato was 36.4%.Conclusions: Our data suggests that C. tetragattii (AFLP7/VGIV) is a more common cause of disease than C. gattii sensu stricto (genotype AFLP4/VGI) among patients with HIV-associated cryptococcal meningitis in Harare, Zimbabwe and possibly underreported in sub-Saharan Africa. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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