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Unusual Synergism of Transferrin and Citrate in the Regulation of Ti(IV) Speciation, Transport, and Toxicity.

Human serum transferrin (sTf) is a protein that mediates the transport of iron from blood to cells. Assisted by the synergistic anion carbonate, sTf transports Fe(III) by binding the metal ion in a closed conformation. Previous studies suggest sTf's role as a potential transporter of other metals su...

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Published in:Journal of the American Chemical Society Vol. 138; no. 17; pp. 5659 - 5666
Main Authors: Tinoco, Arthur D., Saxena, Manoj, Sharma, Shweta, Noinaj, Nicholas, Delgado, Yamixa, Quiñones González, Ernesto P., Conklin, Steven E., Zambrana, Nicole, Loza-Rosas, Sergio A., Parks, Timothy B.
Format: Article
Published: American Chemical Society 5/4/2016
Subjects:
Transferrin
Citrates
Carbonates
Titanium
Metals
Antineoplastic agents
Online Access:View this record in EBSCOhost