Upregulation of inflammatory gene transcripts in periosteum of chronic migraineurs: Implications for extracranial origin of headache.
Objective: Chronic migraine (CM) is often associated with chronic tenderness of pericranial muscles. A distinct increase in muscle tenderness prior to onset of occipital headache that eventually progresses into a full-blown migraine attack is common. This experience raises the possibility that some...
| Publicado en: | Annals of Neurology Vol. 79; no. 6; pp. 1000 - 1014 |
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| Autores principales: | , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Jun2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=115834315&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 115834315 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03645134 1WM jtl: Annals of Neurology issn: 03645134 maglogo: Y pubinfo: dt: Jun2016 vid: 79 iid: 6 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 115834315 115834315 NLM27091721 115834315 10.1002/ana.24665 NLM27091721 PMC4884147 [Available on 06/01/17] 115834315 ppf: 1000 ppct: 14 formats: tig: atl: Upregulation of inflammatory gene transcripts in periosteum of chronic migraineurs: Implications for extracranial origin of headache. aug: au: Perry, Carlton J. Blake, Pamela Buettner, Catherine Papavassiliou, Efstathios Schain, Aaron J. Bhasin, Manoj K. Burstein, Rami affil: River Oaks Plastic Surgery Center, Houston TX sug: subj: Inflammation Migraine Periosteum Metabolism Receptors, Cell Surface Female Proteins Cephalosporins Pharmacodynamics Fasting Isoflurane Pharmacodynamics Young Adult Chronic Disease Case Control Studies Gene Expression Profiling Methods Adult Aged Adolescence Gene Expression Drug Effects Levodopa Pharmacodynamics Male Middle Age Funding Source Human Adult: 19-44 years Aged: 65+ years Adolescent: 13-18 years Middle Aged: 45-64 years Female Male ab: Objective: Chronic migraine (CM) is often associated with chronic tenderness of pericranial muscles. A distinct increase in muscle tenderness prior to onset of occipital headache that eventually progresses into a full-blown migraine attack is common. This experience raises the possibility that some CM attacks originate outside the cranium. The objective of this study was to determine whether there are extracranial pathophysiologies in these headaches.Methods: We biopsied and measured the expression of gene transcripts (mRNA) encoding proteins that play roles in immune and inflammatory responses in affected (ie, where the head hurts) calvarial periosteum of (1) patients whose CMs are associated with muscle tenderness and (2) patients with no history of headache.Results: Expression of proinflammatory genes (eg, CCL8, TLR2) in the calvarial periosteum significantly increased in CM patients attesting to muscle tenderness, whereas expression of genes that suppress inflammation and immune cell differentiation (eg, IL10RA, CSF1R) decreased.Interpretation: Because the upregulated genes were linked to activation of white blood cells, production of cytokines, and inhibition of NF-κB, and the downregulated genes were linked to prevention of macrophage activation and cell lysis, we suggest that the molecular environment surrounding periosteal pain fibers is inflamed and in turn activates trigeminovascular nociceptors that reach the affected periosteum through suture branches of intracranial meningeal nociceptors and/or somatic branches of the occipital nerve. This study provides the first set of evidence for localized extracranial pathophysiology in CM. Ann Neurol 2016;79:1000-1013. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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