Small (<4 cm) clear cell renal cell carcinoma: correlation between CT findings and histologic grade.
Purpose: To evaluate the correlation between CT findings and histologic grade of small clear cell renal cell carcinoma (ccRCC). Methods: CT scans of 101 patients with small ccRCC were reviewed independently by two radiologists for tumor size, shape, margin, encapsulation, enhancement pattern, and vi...
| Publicado en: | Abdominal Radiology Vol. 41; no. 6; pp. 1160 - 1170 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Jun2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=115863282&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 115863282 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 2366004X JT14 jtl: Abdominal Radiology issn: 2366004X maglogo: N pubinfo: dt: Jun2016 vid: 41 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 115863282 10.1007/s00261-016-0732-9 115863282 ppf: 1160 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Small (<4 cm) clear cell renal cell carcinoma: correlation between CT findings and histologic grade. aug: au: Choi, Soo Sung, Deuk Yang, Kyung Kim, Kyeong Yeom, Suk Sim, Ki Han, Na Park, Beom Kim, Min Cho, Sung Lee, Jeong affil: Department of Radiology, Anam Hospital, Korea University College of Medicine, Seoul South Korea sug: ab: Purpose: To evaluate the correlation between CT findings and histologic grade of small clear cell renal cell carcinoma (ccRCC). Methods: CT scans of 101 patients with small ccRCC were reviewed independently by two radiologists for tumor size, shape, margin, encapsulation, enhancement pattern, and visual relative enhancement. Enhancement patterns were defined according to the percentage of uniform enhancement [pattern 1, homogeneous (≥90%); pattern 2, relatively homogeneous (≥75 and <90%); and pattern 3, heterogeneous (<75%)]. Quantitative parameters representing attenuation and degree of enhancement were calculated. Histologic grade was classified as low (Fuhrman grade I or II) and high (Fuhrman grade III or IV). CT imaging variables were analyzed using univariate and multivariate analyses. Results: A total of 63 low-grade and 38 high-grade small ccRCCs were assessed. Low-grade tumors differed from high-grade tumors with respect to enhancement pattern 1 or 2 ( p < 0.001 and p < 0.001), smaller size ( p = 0.002 and p = 0.001), and lower attenuation on unenhanced scan ( p < 0.001 and p = 0.008). In multivariate analysis, enhancement pattern 1 or 2 and low attenuation (≤30 HU) were identified as independent predictors of low-grade ccRCC. Accuracy derived from logistic regression analysis was 79.2% for reader 1 and 70.3% for reader 2. Conclusions: CT imaging features including tumor attenuation and enhancement pattern can be useful to predict the biologic behavior of small ccRCC for adequate treatment strategy. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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