A meta-analysis of cognitive performance in melancholic versus non-melancholic unipolar depression.
Background: Recently there is increasing recognition of cognitive dysfunction as a core feature of Major Depressive Disorder (MDD). The goal of the current meta-analysis was to review and examine in detail the specific features of cognitive dysfunction in Melancholic (MEL) versus Non-Melancholic (NM...
| Published in: | Journal of Affective Disorders Vol. 201; pp. 15 - 25 |
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| Main Authors: | , , , , , , |
| Format: | research systematic review Journal Article |
| Published: |
Elsevier B.V.
Sep2016
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=115918036&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 115918036 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01650327 3M9 jtl: Journal of Affective Disorders issn: 01650327 maglogo: N pubinfo: dt: Sep2016 vid: 201 pid: 1004 pub: Elsevier B.V. artinfo: ui: 115918036 115918036 NLM27156095 115918036 10.1016/j.jad.2016.04.039 NLM27156095 115918036 ppf: 15 ppct: 10 formats: tig: atl: A meta-analysis of cognitive performance in melancholic versus non-melancholic unipolar depression. aug: au: Zaninotto, Leonardo Solmi, Marco Veronese, Nicola Guglielmo, Riccardo Ioime, Lucia Camardese, Giovanni Serretti, Alessandro affil: Department of Biomedical and Neuro-Motor Sciences, University of Bologna, Bologna, Italy sug: subj: Cognition Disorders Psychosocial Factors Depression Psychosocial Factors Depression Complications Cognition Disorders Complications Male Adult Middle Age Cognition Disorders Physiopathology Neuropsychological Tests Depression Physiopathology Female Human Meta Analysis Systematic Review Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Background: Recently there is increasing recognition of cognitive dysfunction as a core feature of Major Depressive Disorder (MDD). The goal of the current meta-analysis was to review and examine in detail the specific features of cognitive dysfunction in Melancholic (MEL) versus Non-Melancholic (NMEL) MDD.Methods: An electronic literature search was performed to find studies comparing cognitive performance in MEL versus NMEL. A meta-analysis of broad cognitive domains (processing speed, reasoning/problem solving, verbal learning, visual learning, attention/working memory) was conducted on all included studies (n=9). Sensitivity and meta-regression analyses were also conducted to detect possible effects of moderator variables (age, gender, education, symptom severity and presence of treatments).Results: MEL patients were older and more severly depressed than NMEL subjects. The MEL group was characterized by a worse cognitive performance in attention/working memory (ES=-0.31), visual learning (ES=-0.35) and reasoning/problem solving (ES=-0.46). No difference was detected in drug-free patients by sensitivity analyses. No effect was found for any of our moderators on the cognitive performance in MEL vs NMEL.Conclusion: Our findings seem to support a moderate but specific effect of melancholic features in affecting the cognitive performance of MDD, in particular as regards visual learning and executive functions. pubtype: Academic Journal doctype: meta analysis research systematic review Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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