Interaction of Cocaine- and Amphetamine-regulated Transcript and Neuropeptide Y on Behavior in the Central Nervous System.
Introduction: In the central nervous system, cocaine- and amphetamine-regulated transcript (CART) 55-102 peptide is localized in areas, such as the ventral tegmental area, amygdala, hypothalamus, and hippocampus, where emotional activity is regulated. Studies on the effects of the intracerebroventri...
| Publicado en: | Archives of Neuropsychiatry / Nöropsikiyatri Arşivi Vol. 53; no. 2; pp. 136 - 144 |
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| Autores principales: | , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Turkish Association of Neuropsychiatry
Jun2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=115922456&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 115922456 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13000667 84NJ jtl: Archives of Neuropsychiatry / Nöropsikiyatri Arşivi issn: 13000667 maglogo: N pubinfo: dt: Jun2016 vid: 53 iid: 2 pid: 32448 pub: Turkish Association of Neuropsychiatry artinfo: ui: 115922456 115922456 115922456 10.5152/npa.2015.9952 115922456 ppf: 136 ppct: 8 formats: tig: atl: Interaction of Cocaine- and Amphetamine-regulated Transcript and Neuropeptide Y on Behavior in the Central Nervous System. aug: au: KIRMIZIBEKMEZ, Aynur MÜDÜROĞLU MENGİ, Murat YURDAKOŞ, Ertan affil: Department of Electroneurophysiology, Nişantaşı University, İstanbul, Turkey sug: subj: Cocaine Amphetamine Neuropeptides Central Nervous System Infusions, Parenteral Animal Studies Rats Antianxiety Agents ab: Introduction: In the central nervous system, cocaine- and amphetamine-regulated transcript (CART) 55-102 peptide is localized in areas, such as the ventral tegmental area, amygdala, hypothalamus, and hippocampus, where emotional activity is regulated. Studies on the effects of the intracerebroventricular (ICV) administration of CART peptide on behavior remain limited. The findings from these studies suggest that this neuropeptide has anxiogenic-like effects. In the central nervous system, neuropeptide Y (NPY) has similar localization as CART. Previous behavioral studies have demonstrated that the ICV administration of NPY has anxiolytic-like effects. Methods: In our study, we established five experimental groups of male Wistar rats to study the competitive effects of NPY and CART peptide. These groups were sham (n=10), CART (n= 10), NPY (n=10), CART-NPY (n= 10), and NPY-CART (n=10). The open field test, elevated plus maze test, and Porsolt swim test were performed for behavioral analyses. Moreover, the rats were decapitated after the behavioral tests, and the amount of these two peptide in their brains was quantified. Results: Our study revealed that the ICV administration of CART peptide is anxiogenic and inhibits animals undergoing learned helplessness in the Porsolt swim test. When we evaluated the results of our study with respect to NPY, we observed its anxiolytic-like effects; in the Porsolt swim test, although it reduced the duration of immobilization, it did not affect the period of struggle. Conclusion: Our results revealed that during the competitive interaction of these two peptides, anxiogenic CART peptide suppressed the anxiolytic effects of NPY. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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