Association between breast cancer, breast density, and body adiposity evaluated by MRI.
Objective: Despite the lack of reliable methods with which to measure breast density from 2D mammograms, numerous studies have demonstrated a positive association between breast cancer and breast density. The goal of this study was to study the association between breast cancer and body adiposity, a...
| Publicado en: | European Radiology Vol. 26; no. 7; pp. 2308 - 2317 |
|---|---|
| Autores principales: | , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jul2016
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=116101200&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 116101200 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Jul2016 vid: 26 iid: 7 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 116101200 116101200 NLM26489749 116101200 10.1007/s00330-015-4058-8 NLM26489749 PMC4840094 [Available on 07/01/17] 116101200 ppf: 2308 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Association between breast cancer, breast density, and body adiposity evaluated by MRI. aug: au: Zhu, Wenlian Huang, Peng Macura, Katarzyna Artemov, Dmitri Macura, Katarzyna J affil: Division of Cancer Imaging Research, Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore 21205 USA sug: subj: Breast Neoplasms Adenocarcinoma Mammography Methods Abdominal Fat Magnetic Resonance Imaging Methods Imaging, Three-Dimensional Retrospective Design Adult Young Adult Adipose Tissue Distribution Age Factors Middle Age Reproducibility of Results Breast Neoplasms Pathology Aged Adenocarcinoma Pathology Aged, 80 and Over Female Human Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Female ab: Objective: Despite the lack of reliable methods with which to measure breast density from 2D mammograms, numerous studies have demonstrated a positive association between breast cancer and breast density. The goal of this study was to study the association between breast cancer and body adiposity, as well as breast density quantitatively assessed from 3D MRI breast images.Methods: Breast density was calculated from 3D T1-weighted MRI images. The thickness of the upper abdominal adipose layer was used as a surrogate marker for body adiposity. We evaluated the correlation between breast density, age, body adiposity, and breast cancer.Results: Breast density was calculated for 410 patients with unilateral invasive breast cancer, 73 patients with ductal carcinoma in situ (DCIS), and 361 controls without breast cancer. Breast density was inversely related to age and the thickness of the upper abdominal adipose layer. Breast cancer was only positively associated with body adiposity and age.Conclusion: Age and body adiposity are predictive of breast density. Breast cancer was not associated with breast density; however, it was associated with the thickness of the upper abdominal adipose layer, a surrogate marker for body adiposity. Our results based on a limited number of patients warrant further investigations.Key Points: • MRI breast density is negatively associated with body adiposity. • MRI breast density is negatively associated with age. • Breast cancer is positively associated with body adiposity. • Breast Cancer is not associated with MRI breast density. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|