Comparison of diagnostic performance for perinatal and paediatric post-mortem imaging: CT versus MRI.
Objectives: To compare the diagnostic yield of whole-body post-mortem computed tomography (PMCT) imaging to post-mortem magnetic resonance (PMMR) imaging in a prospective study of fetuses and children.Methods: We compared PMCT and PMMR to conventional autopsy as the gold standard for the detection o...
| Publicado en: | European Radiology Vol. 26; no. 7; pp. 2327 - 2337 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | diagnostic images pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jul2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=116101201&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 116101201 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Jul2016 vid: 26 iid: 7 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 116101201 116101201 NLM26489748 116101201 10.1007/s00330-015-4057-9 NLM26489748 116101201 ppf: 2327 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Comparison of diagnostic performance for perinatal and paediatric post-mortem imaging: CT versus MRI. aug: au: Arthurs, Owen Guy, Anna Thayyil, Sudhin Wade, Angie Jones, Rod Norman, Wendy Scott, Rosemary Robertson, Nicola Jacques, Thomas Chong, W. Gunny, Roxanna Saunders, Dawn Olsen, Oystein Owens, Catherine Offiah, Amaka Chitty, Lyn Taylor, Andrew Sebire, Neil Arthurs, Owen J Robertson, Nicola J affil: Great Ormond Street Hospital NHS Foundation Trust, London UK sug: subj: Tomography, X-Ray Computed Methods Autopsy Methods Diagnostic Imaging Methods Magnetic Resonance Imaging Methods Male Prospective Studies Pregnancy Infant, Newborn Female Infant Child, Preschool Adolescence Reproducibility of Results Human Child Validation Studies Comparative Studies Evaluation Research Multicenter Studies Funding Source Fetus Infant, Newborn: birth-1 month Infant: 1-23 months Child, Preschool: 2-5 years Adolescent: 13-18 years Child: 6-12 years Fetus, conception to birth Male Female ab: Objectives: To compare the diagnostic yield of whole-body post-mortem computed tomography (PMCT) imaging to post-mortem magnetic resonance (PMMR) imaging in a prospective study of fetuses and children.Methods: We compared PMCT and PMMR to conventional autopsy as the gold standard for the detection of (a) major pathological abnormalities related to the cause of death and (b) all diagnostic findings in five different body organ systems.Results: Eighty two cases (53 fetuses and 29 children) underwent PMCT and PMMR prior to autopsy, at which 55 major abnormalities were identified. Significantly more PMCT than PMMR examinations were non-diagnostic (18/82 vs. 4/82; 21.9 % vs. 4.9 %, diff 17.1 % (95 % CI 6.7, 27.6; p < 0.05)). PMMR gave an accurate diagnosis in 24/55 (43.64 %; 95 % CI 31.37, 56.73 %) compared to 18/55 PMCT (32.73 %; 95 % CI 21.81, 45.90). PMCT was particularly poor in fetuses <24 weeks, with 28.6 % (8.1, 46.4 %) more non-diagnostic scans. Where both PMCT and PMMR were diagnostic, PMMR gave slightly higher diagnostic accuracy than PMCT (62.8 % vs. 59.4 %).Conclusion: Unenhanced PMCT has limited value in detection of major pathology primarily because of poor-quality, non-diagnostic fetal images. On this basis, PMMR should be the modality of choice for non-invasive PM imaging in fetuses and children.Key Points: • Overall 17.1 % more PMCT examinations than PMMR were non-diagnostic • 28.6 % more PMCT were non-diagnostic than PMMR in fetuses <24 weeks • PMMR detected almost a third more pathological abnormalities than PMCT • PMMR gave slightly higher diagnostic accuracy when both were diagnostic. pubtype: Academic Journal doctype: diagnostic images pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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