Quantitative 3D analysis of bone in hip osteoarthritis using clinical computed tomography.
Objective: To assess the relationship between proximal femoral cortical bone thickness and radiological hip osteoarthritis using quantitative 3D analysis of clinical computed tomography (CT) data.Methods: Image analysis was performed on clinical CT imaging data from 203 female volunteers with a tech...
| Publicado en: | European Radiology Vol. 26; no. 7; pp. 2047 - 2055 |
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| Autores principales: | , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Jul2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=116101209&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 116101209 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Jul2016 vid: 26 iid: 7 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 116101209 116101209 NLM26443603 10.1007/s00330-015-4048-x NLM26443603 PMC4902845 116101209 ppf: 2047 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Quantitative 3D analysis of bone in hip osteoarthritis using clinical computed tomography. aug: au: Turmezei, Tom Treece, Graham Gee, Andrew Fotiadou, Anastasia Poole, Kenneth Turmezei, Tom D Treece, Graham M Gee, Andrew H Fotiadou, Anastasia F Poole, Kenneth E S affil: Department of Engineering, University of Cambridge, Trumpington Street Cambridge CB2 1PZ UK sug: subj: Imaging, Three-Dimensional Methods Femur Head Pathology Osteoarthritis, Hip Pathology Femur Neck Pathology Tomography, X-Ray Computed Methods Ossification, Heterotopic Pathology Risk Factors Severity of Illness Indices Osteoarthritis, Hip Ossification, Heterotopic Middle Age Aged, 80 and Over Female Aged Scales Middle Aged: 45-64 years Aged, 80 & over Aged: 65+ years Female ab: Objective: To assess the relationship between proximal femoral cortical bone thickness and radiological hip osteoarthritis using quantitative 3D analysis of clinical computed tomography (CT) data.Methods: Image analysis was performed on clinical CT imaging data from 203 female volunteers with a technique called cortical bone mapping (CBM). Colour thickness maps were created for each proximal femur. Statistical parametric mapping was performed to identify statistically significant differences in cortical bone thickness that corresponded with the severity of radiological hip osteoarthritis. Kellgren and Lawrence (K&L) grade, minimum joint space width (JSW) and a novel CT-based osteophyte score were also blindly assessed from the CT data.Results: For each increase in K&L grade, cortical thickness increased by up to 25 % in distinct areas of the superolateral femoral head-neck junction and superior subchondral bone plate. For increasing severity of CT osteophytes, the increase in cortical thickness was more circumferential, involving a wider portion of the head-neck junction, with up to a 7 % increase in cortical thickness per increment in score. Results were not significant for minimum JSW.Conclusions: These findings indicate that quantitative 3D analysis of the proximal femur can identify changes in cortical bone thickness relevant to structural hip osteoarthritis.Key Points: • CT is being increasingly used to assess bony involvement in osteoarthritis • CBM provides accurate and reliable quantitative analysis of cortical bone thickness • Cortical bone is thicker at the superior femoral head-neck with worse osteoarthritis • Regions of increased thickness co-locate with impingement and osteophyte formation • Quantitative 3D bone analysis could enable clinical disease prediction and therapy development. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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