Imagen de Portada
Código QR

MRI and contrast-enhanced ultrasound imaging for evaluation of focal irreversible electroporation treatment: results from a phase I-II study in patients undergoing IRE followed by radical prostatectomy.

Objectives: Irreversible electroporation (IRE) is an ablative therapy with a low side-effect profile in prostate cancer. The objective was: 1) To compare the volumetric IRE ablation zone on grey-scale transrectal ultrasound (TRUS), contrast-enhanced ultrasound (CEUS) and multiparametric MRI (mpMRI)...

Descripción completa

Publicado en:European Radiology Vol. 26; no. 7; pp. 2252 - 2261
Autores principales: van den Bos, Willemien, Bruin, D., Randen, A., Engelbrecht, M., Postema, A., Muller, B., Varkarakis, I., Skolarikos, A., Savci-Heijink, C., Jurhill, R., Zondervan, P., Laguna Pes, M., Wijkstra, H., Reijke, T., Rosette, J., de Bruin, D M, van Randen, A, Engelbrecht, M R W, Postema, A W, Muller, B G
Formato: clinical trial research Journal Article
Publicado: Springer Nature Jul2016
Acceso en línea:Ver este registro en EBSCOhost
fields @attributes:
  recordID: 1
pdfLink:
plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=116101214&site=ehost-live
header:
  @attributes:
    shortDbName: ccm
    uiTerm: 116101214
    longDbName: CINAHL Complete
    uiTag: AN
  controlInfo:
    bkinfo:
    dissinfo:
    jinfo:
      jid:
        09387994
        NPH
      jtl: European Radiology
      issn: 09387994
      maglogo: N
    pubinfo:
      dt: Jul2016
      vid: 26
      iid: 7
      pid: 237
      pub: Springer Nature
      place: New York, New York
    artinfo:
      ui:
        116101214
        116101214
        NLM26449559
        116101214
        10.1007/s00330-015-4042-3
        NLM26449559
        PMC4902838
        116101214
      ppf: 2252
      ppct: 9
      formats:
        fmt:
          @attributes:
            type: P
      tig:
        atl: MRI and contrast-enhanced ultrasound imaging for evaluation of focal irreversible electroporation treatment: results from a phase I-II study in patients undergoing IRE followed by radical prostatectomy.
      aug:
        au:
          van den Bos, Willemien
          Bruin, D.
          Randen, A.
          Engelbrecht, M.
          Postema, A.
          Muller, B.
          Varkarakis, I.
          Skolarikos, A.
          Savci-Heijink, C.
          Jurhill, R.
          Zondervan, P.
          Laguna Pes, M.
          Wijkstra, H.
          Reijke, T.
          Rosette, J.
          de Bruin, D M
          van Randen, A
          Engelbrecht, M R W
          Postema, A W
          Muller, B G
        affil: Department of Radiology, Academic Medical Center, University of Amsterdam, 1100 DD Amsterdam The Netherlands
      sug:
        subj:
          Contrast Media
          Cytological Techniques Methods
          Image Enhancement Methods
          Magnetic Resonance Imaging Methods
          Ultrasonography Methods
          Prostatic Neoplasms Therapy
          Prostate
          Aged
          Male
          Prospective Studies
          Adult
          Prostatic Neoplasms Surgery
          Treatment Outcomes
          Human
          Prostatectomy
          Reproducibility of Results
          Middle Age
          Clinical Trials
          Validation Studies
          Comparative Studies
          Evaluation Research
          Multicenter Studies
          Aged: 65+ years
          Adult: 19-44 years
          Middle Aged: 45-64 years
          Male
      ab: Objectives: Irreversible electroporation (IRE) is an ablative therapy with a low side-effect profile in prostate cancer. The objective was: 1) To compare the volumetric IRE ablation zone on grey-scale transrectal ultrasound (TRUS), contrast-enhanced ultrasound (CEUS) and multiparametric MRI (mpMRI) with histopathology findings; 2) To determine a reliable imaging modality to visualize the IRE ablation effects accurately.Methods: A prospective phase I-II study was performed in 16 patients scheduled for radical prostatectomy (RP). IRE of the prostate was performed 4 weeks before RP. Prior to, and 4 weeks after the IRE treatment, imaging was performed by TRUS, CEUS, and mpMRI. 3D-analysis of the ablation volumes on imaging and on H&E-stained whole-mount sections was performed. The volumes were compared and the correlation was calculated.Results: Evaluation of the imaging demonstrated that with T2-weighted MRI, dynamic contrast enhanced (DCE) MRI, and CEUS, effects of IRE are visible. T2MRI and CEUS closely match the volumes on histopathology (Pearson correlation r = 0.88 resp. 0.80). However, IRE is not visible with TRUS.Conclusions: mpMRI and CEUS are appropriate for assessing IRE effects and are the most feasible imaging modalities to visualize IRE ablation zone. The imaging is concordant with results of histopathological examination.Key Points: • mpMRI and contrast-enhanced ultrasound are appropriate imaging modalities for assessing IRE effects • mpMRI and CEUS are the most feasible imaging modalities to visualize IRE ablation zone • The imaging is concordant with results of histopathological examination after IRE • Grey-scale US is insufficient for assessing IRE ablations.
      pubtype: Academic Journal
      doctype:
        clinical trial
        research
        Journal Article
      ougenre: Article
    language: English
    refInfo:
    holdings:
      @attributes:
        islocal: N