Nicotine withdrawal alters neural responses to psychosocial stress.
Introduction: Psychosocial stress is considered to be an important mechanism underlying smoking behavior and relapse. Thus, understanding the effects of acute nicotine withdrawal on responses to stress is important to intervene to prevent stress-induced relapse. The current study investigated the ne...
| Publicado en: | Psychopharmacology Vol. 233; no. 13; pp. 2459 - 2468 |
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| Autores principales: | , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Jul2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=116146512&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 116146512 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00333158 EJD jtl: Psychopharmacology issn: 00333158 maglogo: N pubinfo: dt: Jul2016 vid: 233 iid: 13 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 116146512 10.1007/s00213-016-4299-5 116146512 ppf: 2459 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Nicotine withdrawal alters neural responses to psychosocial stress. aug: au: Ashare, Rebecca Lerman, Caryn Cao, Wen Falcone, Mary Bernardo, Leah Ruparel, Kosha Hopson, Ryan Gur, Ruben Pruessner, Jens Loughead, James affil: Center for Interdisciplinary Research on Nicotine Addiction, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, 3535 Market St., Suite 4100 Philadelphia 19104 USA sug: ab: Introduction: Psychosocial stress is considered to be an important mechanism underlying smoking behavior and relapse. Thus, understanding the effects of acute nicotine withdrawal on responses to stress is important to intervene to prevent stress-induced relapse. The current study investigated the neural correlates of psychosocial stress during acute nicotine withdrawal in chronic smokers. Methods: Thirty-nine treatment-seeking smokers were randomized to one of two conditions (abstinent 24 h ( n = 21) or smoking as usual ( n = 18)). They were then exposed to the Montreal Imaging Stress Task (MIST), a psychosocial stress task consisting of difficult mental arithmetic problems while receiving negative performance feedback while undergoing functional magnetic resonance imaging (fMRI). Results: Subjective measures of stress increased following the MIST, compared to baseline. Whole brain between-group analysis identified significant activation clusters in four regions for the stress induction minus control contrast: inferior frontal gyrus (IFG), anterior/para cingulate cortex (ACC), precuneus, and supramarginal gyrus (SMG). In all regions, the deprived group showed significantly greater activation compared to the non-deprived group. No significant correlations were found between subjective stress and BOLD signal activation ( ps > 0.07). Conclusions: This study provides new evidence that brain regions previously shown to be predictive of relapse, such as the precuneus and IFG, display heightened neural responses to stress during nicotine deprivation. These data identify the brain regions that may be associated with withdrawal-related stress responses. Increased stress-related activation during nicotine withdrawal may identify those most vulnerable to relapse and represent a target for novel pharmacological intervention. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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