Cognitive activity, cognitive function, and brain diffusion characteristics in old age.
The objective of this work was to test the hypotheses that a) more frequent cognitive activity in late life is associated with higher brain diffusion anisotropy and lower trace of the diffusion tensor, and b) brain diffusion characteristics partially mediate the association of late life cognitive ac...
| Publicado en: | Brain Imaging & Behavior Vol. 10; no. 2; pp. 455 - 464 |
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| Autores principales: | , , , , , , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jun2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=116148066&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 116148066 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Jun2016 vid: 10 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 116148066 116148066 NLM25982658 116148066 10.1007/s11682-015-9405-5 NLM25982658 PMC4646719 [Available on 06/01/17] 116148066 ppf: 455 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Cognitive activity, cognitive function, and brain diffusion characteristics in old age. aug: au: Arfanakis, Konstantinos Wilson, Robert Barth, Christopher Capuano, Ana Vasireddi, Anil Zhang, Shengwei Fleischman, Debra Bennett, David Wilson, Robert S Barth, Christopher M Capuano, Ana W Fleischman, Debra A Bennett, David A affil: Department of Biomedical Engineering, Medical Imaging Research Center, M-102, Illinois Institute of Technology, 3440 South Dearborn St. Chicago 60616 USA sug: subj: Brain Pathology Cognition Age Factors Magnetic Resonance Imaging Methods Prospective Studies Aged Aged, 80 and Over Image Processing, Computer Assisted Magnetic Resonance Imaging Cognition Disorders Male Female Funding Source Human Aged: 65+ years Aged, 80 & over Male Female ab: The objective of this work was to test the hypotheses that a) more frequent cognitive activity in late life is associated with higher brain diffusion anisotropy and lower trace of the diffusion tensor, and b) brain diffusion characteristics partially mediate the association of late life cognitive activity with cognition. As part of a longitudinal cohort study, 379 older people without dementia rated their frequency of participation in cognitive activities, completed a battery of cognitive function tests, and underwent diffusion tensor imaging. We used tract-based spatial statistics to test the association between late life cognitive activity and brain diffusion characteristics. Clusters with statistically significant findings defined regions of interest in which we tested the hypothesis that diffusion characteristics partially mediate the association of late life cognitive activity with cognition. More frequent cognitive activity in late life was associated with higher level of global cognition after adjustment for age, sex, education, and indicators of early life cognitive enrichment (p = 0.001). More frequent cognitive activity was also related to higher fractional anisotropy in the left superior and inferior longitudinal fasciculi, left fornix, and corpus callosum, and lower trace in the thalamus (p < 0.05, FWE-corrected). After controlling for fractional anisotropy or trace from these regions, the regression coefficient for the association of late life cognitive activity with cognition was reduced by as much as 26 %. These findings suggest that the association of late life cognitive activity with cognition may be partially mediated by brain diffusion characteristics. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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