Magnetic resonance imaging structural alterations in brain of alcohol abusers and its association with impulsivity.
Despite the suggestion that impulsivity plays a central role in the transfer from a recreational drug use to a substance use disorder, very few studies focused on neurobiological markers for addiction. This study aimed to identify volumetric alterations in a sample of patients with mild alcohol use...
| Publicado en: | Addiction Biology Vol. 21; no. 4; pp. 962 - 972 |
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| Autores principales: | , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Jul2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=116193261&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 116193261 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13556215 ADB jtl: Addiction Biology issn: 13556215 maglogo: Y pubinfo: dt: Jul2016 vid: 21 iid: 4 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 116193261 116193261 NLM25988724 116193261 10.1111/adb.12257 NLM25988724 116193261 ppf: 962 ppct: 10 formats: tig: atl: Magnetic resonance imaging structural alterations in brain of alcohol abusers and its association with impulsivity. aug: au: Asensio, Samuel Morales, Julia L. Senabre, Isabel Romero, Maria J. Beltran, Miguel A. Flores‐Bellver, Miguel Barcia, Jorge M. Romero, Francisco J. affil: Facultad de Ciencias de la Salud, Universidad Cardenal Herrera‐CEU, Spain sug: subj: Magnetic Resonance Imaging Methods Behavior Brain Pathology Brain Mapping Methods Brain Alcoholism Pathology Young Adult Adolescence Neuropsychological Tests Statistics and Numerical Data Body Weights and Measures Male Image Processing, Computer Assisted Methods Adult Middle Age Human Adolescent: 13-18 years Adult: 19-44 years Middle Aged: 45-64 years Male ab: Despite the suggestion that impulsivity plays a central role in the transfer from a recreational drug use to a substance use disorder, very few studies focused on neurobiological markers for addiction. This study aimed to identify volumetric alterations in a sample of patients with mild alcohol use disorder with a short history of alcohol use, compared with a control group, and also focused on its association with impulsivity levels. Most magnetic resonance imaging studies have focused on severe alcohol use disorder, formerly called alcohol-dependent patients, showing alcohol-related structural alterations and their association with alcohol use history variables but not with personality parameters like impulsivity. Our hypothesis is that our group of alcohol users may already display structural alterations especially in brain regions related to inhibitory control like medial-prefrontal regions, and that those structural alterations could be more associated to personality traits like impulsivity than to drug use variables. Our results clearly demonstrate that our population showed lower regional grey and white matter volumes in the medial-prefrontal and orbitofrontal cortices, as well as higher regional white matter volume in the ventral striatum and the internal capsule. Volumetric alterations were associated to the Barratt's impulsivity score: the more impulsive the subjects, the lower the medial-prefrontal cortex grey matter volume. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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