Lower gray matter density and functional connectivity in the anterior insula in smokers compared with never smokers.
Although nicotine addiction is characterized by both structural and functional abnormalities in brain networks involved in salience and cognitive control, few studies have integrated these data to understand how these abnormalities may support addiction. This study aimed to (1) evaluate gray matter...
| Publicado en: | Addiction Biology Vol. 21; no. 4; pp. 972 - 982 |
|---|---|
| Autores principales: | , , , , |
| Formato: | Journal Article |
| Publicado: |
Wiley-Blackwell
Jul2016
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=116193272&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 116193272 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13556215 ADB jtl: Addiction Biology issn: 13556215 maglogo: Y pubinfo: dt: Jul2016 vid: 21 iid: 4 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 116193272 116193272 NLM25990865 10.1111/adb.12262 NLM25990865 PMC4654721 [Available on 07/01/17] 116193272 ppf: 972 ppct: 10 formats: tig: atl: Lower gray matter density and functional connectivity in the anterior insula in smokers compared with never smokers. aug: au: Stoeckel, Luke E. Chai, Xiaoqian J. Zhang, Jiahe Whitfield‐Gabrieli, Susan Evins, A. Eden affil: Department of Psychiatry, Massachusetts General Hospital, Boston MA, USA sug: ab: Although nicotine addiction is characterized by both structural and functional abnormalities in brain networks involved in salience and cognitive control, few studies have integrated these data to understand how these abnormalities may support addiction. This study aimed to (1) evaluate gray matter density and functional connectivity of the anterior insula in cigarette smokers and never smokers and (2) characterize how differences in these measures were related to smoking behavior. We compared structural magnetic resonance imaging (MRI) (gray matter density via voxel-based morphometry) and seed-based functional connectivity MRI data in 16 minimally deprived smokers and 16 matched never smokers. Compared with controls, smokers had lower gray matter density in left anterior insula extending into inferior frontal and temporal cortex. Gray matter density in this region was inversely correlated with cigarettes smoked per day. Smokers exhibited negative functional connectivity (anti-correlation) between the anterior insula and regions involved in cognitive control (left lPFC) and semantic processing/emotion regulation (lateral temporal cortex), whereas controls exhibited positive connectivity between these regions. There were differences in the anterior insula, a central region in the brain's salience network, when comparing both volumetric and functional connectivity data between cigarette smokers and never smokers. Volumetric data, but not the functional connectivity data, were also associated with an aspect of smoking behavior (daily cigarettes smoked). pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|