Helicobacter hepaticus model of infection: the human hepatocellular carcinoma controversy.

The discovery of Helicobacter 30 years ago by Marshall and Warren completely changed thought about peptic and duodenal ulcers. The previous paradigm posited the impossibility of the survival of microorganisms in the stomach's low pH environment and that, if any microorganisms survived, they would st...

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Publicado en:Revista Colombiana de Gastroenterología Vol. 28; no. 4; pp. 315 - 323
Autores principales: Zapata, Yessica Agudelo, Llano, Rodrigo Castaño, Corredor, Mauricio
Formato: Artículo
Publicado: Asociacion Colombiana de Gastroenterologia oct-dec2013
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Acceso en línea:Ver este registro en EBSCOhost
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          Zapata, Yessica Agudelo
          Llano, Rodrigo Castaño
          Corredor, Mauricio
        affil:
          Medical Doctor and General Surgeon in the Gastrohepatology Group at Universidad de Antioquia in Medellin, Colombia
          Gastrointestinal Surgeon and Endoscopist in the Gastrohepatology Group at the Universidad de Antioquia in Medellin, Colombia
          Institute Professor of Biology in the Faculty of Natural Sciences and the GEBIOMIC Group the Gastroenterology Group at the Universidad de Antioquia in Medellin, Colombia
      su:
        Helicobacter pylori
        Helicobacter diseases
        Liver cancer
      sug:
        subj:
          Helicobacter pylori
          Helicobacter diseases
          Liver cancer
      keyword:
        Helicobacter hepaticus
        Helicobacter spp.
        hepatocellular carcinoma
      ab: The discovery of Helicobacter 30 years ago by Marshall and Warren completely changed thought about peptic and duodenal ulcers. The previous paradigm posited the impossibility of the survival of microorganisms in the stomach's low pH environment and that, if any microorganisms survived, they would stay in the duodenum or elsewhere in the intestine. Today the role of H. pylori in carcinogenesis is indisputable, but little is known about other emerging species of the genus Helicobacter in humans. Helicobacter hepaticus is one of these species that has been studied most, after H. pylori. We now know about their microbiological, genetic and pathogenic relationships with HCC in murine and human infections. This review aims to show the medical and scientifi c community the existence of new species of Helicobacter that have pathogenic potential in humans, thus encouraging research.
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    language: English
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