Generation of data on within-subject biological variation in laboratory medicine: An update.
In recent decades, the study of biological variation of laboratory analytes has received increased attention. The reasons for this interest are related to the potential practical applications of such knowledge. Biological variation data allow the derivation of important parameters for the interpreta...
| Publicado en: | Critical Reviews in Clinical Laboratory Sciences Vol. 53; no. 5; pp. 313 - 326 |
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| Autores principales: | , |
| Formato: | algorithm review tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Oct2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=116262642&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 116262642 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10408363 1AV jtl: Critical Reviews in Clinical Laboratory Sciences issn: 10408363 maglogo: Y pubinfo: dt: Oct2016 vid: 53 iid: 5 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 116262642 116262642 116262642 10.3109/10408363.2016.1150252 116262642 ppf: 313 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Generation of data on within-subject biological variation in laboratory medicine: An update. aug: au: Braga, Federica Panteghini, Mauro affil: Centre for Metrological Traceability in Laboratory Medicine (CIRME), University of Milan, Milano, Italy sug: subj: Genotype Diagnosis, Laboratory Clinical Laboratories Reference Values Laboratory Test Interference Laboratory Test Panels Reference Databases Checklists ab: In recent decades, the study of biological variation of laboratory analytes has received increased attention. The reasons for this interest are related to the potential practical applications of such knowledge. Biological variation data allow the derivation of important parameters for the interpretation and use of laboratory tests, such as the index of individuality for the evaluation of the utility of population reference intervals for the test interpretation, the estimate of significant change in a timed series of results of an individual, the number of specimens required to obtain an accurate estimate of the homeostatic set point of the analyte and analytical performance specifications that assays should fulfill for their application in the clinical setting. It is, therefore, essential to experimentally derive biological variation information in an accurate and reliable way. Currently, a dated guideline for the biological variation data production and a more recent checklist to assist in the correct preparation of publications related to biological variation studies are available. Here, we update and integrate, with examples, the available guideline for biological variation data production to help researchers to comply with the recommendations of the checklist for drafting manuscripts on biological variation. Particularly, we focus on the distribution of the data, an essential aspect to be considered for the derivation of biological variation data. Indeed, the difficulty in deriving reliable estimates of biological variation for those analytes, the measured concentrations of which are not normally distributed, is more and more evident. pubtype: Academic Journal doctype: algorithm review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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