Disease activity accounts for long-term efficacy of IL-1 blockers in pyogenic sterile arthritis pyoderma gangrenosum and severe acne syndrome.

Objective. To provide a rationale for anti-IL-1 treatment in pyogenic sterile arthritis, pyoderma gangrenosum and acne (PAPA) by defining whether IL-1β secretion is enhanced; requires NLRP3; and correlates with proline-serine-threonine phosphatase-interacting protein 1 mutations, disease activity an...

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Publicado en:	Rheumatology Vol. 55; no. 7; pp. 1325 - 1336
Autores principales:	Omenetti, Alessia, Carta, Sonia, Caorsi, Roberta, Finetti, Martina, Marotto, Daniela, Lattanzi, Bianca, Jorini, Mauro, Delfino, Laura, Penco, Federica, Picco, Paolo, Buoncompagni, Antonella, Martini, Alberto, Rubartelli, Anna, Gattorno, Marco
Formato:	pictorial research tables/charts Journal Article
Publicado:	Oxford University Press / USA Jul2016
Acceso en línea:	Ver este registro en EBSCOhost