Myocardial Infarction-Associated Transcript, a Long Noncoding RNA, Is Overexpressed During Dilated Cardiomyopathy Due to Chronic Chagas Disease.
Long noncoding RNAs (lncRNAs) modulate gene expression at the epigenetic, transcriptional, and posttranscriptional levels. Dysregulation of the lncRNA known as myocardial infarction-associated transcript (MIAT) has been associated with myocardial infarction. Chagas disease causes a severe inflammato...
| Publicado en: | Journal of Infectious Diseases Vol. 214; no. 1; pp. 161 - 166 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Oxford University Press / USA
7/1/2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=116361850&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 116361850 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00221899 1YU jtl: Journal of Infectious Diseases issn: 00221899 maglogo: N pubinfo: dt: 7/1/2016 vid: 214 iid: 1 pid: 622 pub: Oxford University Press / USA artinfo: ui: 116361850 116361850 NLM26951817 116361850 10.1093/infdis/jiw095 NLM26951817 116361850 ppf: 161 ppct: 5 formats: tig: atl: Myocardial Infarction-Associated Transcript, a Long Noncoding RNA, Is Overexpressed During Dilated Cardiomyopathy Due to Chronic Chagas Disease. aug: au: Farage Frade, Amanda Laugier, Laurie Rodrigues Pinto Ferreira, Ludmila Andrade Baron, Monique Benvenuti, Luiz Alberto Camillo Teixeira, Priscila Cunha Navarro, Isabela Cabantous, Sandrine Moraes Ferreira, Frederico da Silva Cândido, Darlan Gaiotto, Fabio Antônio Bacal, Fernando Pomerantzeff, Pablo Barros Santos, Ronaldo Honorato Kalil, Jorge Cunha-Neto, Edecio Chevillard, Christophe Frade, Amanda Farage Ferreira, Ludmila Rodrigues Pinto Baron, Monique Andrade affil: Aix-Marseille Université, INSERM, GIMP UMR_S906, 13385, France sug: subj: Myocardial Infarction Trypanosomiasis Complications Gene Expression Profiling Myocardial Infarction Etiology RNA Trypanosomiasis Mice Animal Studies Male Transcription Factors Trypanosomiasis Physiopathology Female Human Male Female ab: Long noncoding RNAs (lncRNAs) modulate gene expression at the epigenetic, transcriptional, and posttranscriptional levels. Dysregulation of the lncRNA known as myocardial infarction-associated transcript (MIAT) has been associated with myocardial infarction. Chagas disease causes a severe inflammatory dilated chronic cardiomyopathy (CCC). We investigated the role of MIAT in CCC. A whole-transcriptome analysis of heart biopsy specimens and formalin-fixed, paraffin-embedded samples revealed that MIAT was overexpressed in patients with CCC, compared with subjects with noninflammatory dilated cardiomyopathy and controls. These results were confirmed in a mouse model. Results suggest that MIAT is a specific biomarker of CCC. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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