Maternal prenatal intake of one-carbon metabolism nutrients and risk of childhood leukemia.
Purpose: Folate, vitamins B12 and B6, riboflavin, and methionine are critical nutrients for the one-carbon metabolism cycle involved in DNA synthesis and epigenetic processes. We examined the association between maternal intake of these nutrients before pregnancy and risk of childhood acute lymphobl...
| Publicado en: | Cancer Causes & Control Vol. 27; no. 7; pp. 929 - 941 |
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| Autores principales: | , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jul2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=116415321&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 116415321 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09575243 ODX jtl: Cancer Causes & Control issn: 09575243 maglogo: N pubinfo: dt: Jul2016 vid: 27 iid: 7 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 116415321 116415321 NLM27294727 116415321 10.1007/s10552-016-0773-y NLM27294727 PMC4939072 [Available on 07/01/17] 116415321 ppf: 929 ppct: 12 formats: fmt: @attributes: type: P tig: atl: Maternal prenatal intake of one-carbon metabolism nutrients and risk of childhood leukemia. aug: au: Singer, Amanda Selvin, Steve Block, Gladys Golden, Carla Carmichael, Suzan Metayer, Catherine Singer, Amanda W Carmichael, Suzan L affil: Division of Epidemiology, School of Public Health, University of California, Berkeley, 1995 University Avenue, Suite 460 Berkeley 94704 USA sug: subj: Prenatal Care Leukemia, Lymphocytic, Acute Epidemiology Dietary Supplements Infant Adult Hispanic Americans Child Riboflavin Administration and Dosage Risk Factors Methionine Administration and Dosage Female Odds Ratio Vitamin B12 Administration and Dosage Case Control Studies California Child, Preschool Male Adolescence Infant, Newborn Pregnancy Logistic Regression Folic Acid Administration and Dosage Energy Intake Carbon Metabolism Pyridoxine Administration and Dosage Questionnaires Funding Source Human Infant: 1-23 months Adult: 19-44 years Child: 6-12 years Child, Preschool: 2-5 years Adolescent: 13-18 years Infant, Newborn: birth-1 month Female Male ab: Purpose: Folate, vitamins B12 and B6, riboflavin, and methionine are critical nutrients for the one-carbon metabolism cycle involved in DNA synthesis and epigenetic processes. We examined the association between maternal intake of these nutrients before pregnancy and risk of childhood acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) in a matched case-control study.Methods: Maternal dietary intake and vitamin supplement use in the year before pregnancy was assessed by food frequency questionnaire for 681 ALL cases, 103 AML cases, and 1076 controls. Principal component analysis was used to construct a variable representing combined nutrient intake, and conditional logistic regression estimated the odds ratio (OR) and 95% confidence interval (CI) for the association of ALL and AML with the principal component and each nutrient.Results: Higher maternal intake of one-carbon metabolism nutrients from food and supplements combined was associated with reduced risk of ALL (OR for one-unit change in the principal component = 0.91, CI 0.84-0.99) and possibly AML (OR for the principal component = 0.83, CI 0.66-1.04). When analyzed separately, intake of supplements high in these nutrients was associated with a reduced risk of ALL in children of Hispanic women only.Conclusions: In conclusion, these data suggest that higher maternal intake of one-carbon metabolism nutrients may reduce risk of childhood leukemia. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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