Changes and variability of proton density and T1 relaxation times in early multiple sclerosis: MRI markers of neuronal damage in the cerebral cortex.
Objectives: Proton density (PD) and T1 relaxation time are promising quantitative MRI (qMRI) markers of neuronal damage in multiple sclerosis (MS). However, it is unknown whether cortical differences of these parameters between patients and controls exist in the early stages of disease. This study i...
| Publicado en: | European Radiology Vol. 26; no. 8; pp. 2578 - 2587 |
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| Autores principales: | , , , , , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Aug2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=116510177&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 116510177 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Aug2016 vid: 26 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 116510177 116510177 NLM26494641 116510177 10.1007/s00330-015-4072-x NLM26494641 116510177 ppf: 2578 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Changes and variability of proton density and T1 relaxation times in early multiple sclerosis: MRI markers of neuronal damage in the cerebral cortex. aug: au: Gracien, René-Maxime Reitz, Sarah Hof, Stephanie Fleischer, Vinzenz Zimmermann, Hilga Droby, Amgad Steinmetz, Helmuth Zipp, Frauke Deichmann, Ralf Klein, Johannes Gracien, René-Maxime Reitz, Sarah C Hof, Stephanie Michelle Klein, Johannes C affil: Neuroimaging Center (NIC) of the Focus Program Translational Neuroscience (FTN), University Hospital, Gutenberg University, Mainz Germany sug: subj: Magnetic Resonance Imaging Methods Multiple Sclerosis Diagnosis Cerebral Cortex Female Male Gray Matter Adult Checklists Human Adult: 19-44 years Female Male ab: Objectives: Proton density (PD) and T1 relaxation time are promising quantitative MRI (qMRI) markers of neuronal damage in multiple sclerosis (MS). However, it is unknown whether cortical differences of these parameters between patients and controls exist in the early stages of disease. This study investigates cortical T1 and PD in early MS stages, hypothesizing that these are altered and display a high spatial variability.Methods: Quantitative T1 and PD mapping was performed on 11 patients with clinically isolated syndrome (CIS)/early MS in remission and 11 healthy controls. The normal appearing cortical gray matter was extracted, lobar regions were identified, and mean values and standard deviations of both parameters were calculated within each region.Results: Increased PD was detected in MS/CIS patients in the cerebral cortex as a whole and all subregions, indicating an increase of water content. Increase of PD variability reached significance in the whole cortex and in the frontal and parietal regions. Longer T1 relaxation times and increased variability were found in the cerebral cortex in all regions studied, indicating a change of microstructural tissue composition that is spatially heterogeneous.Conclusions: The data show spatially heterogeneous cortical involvement in early MS is reflected in T1 and PD qMRI.Key Points: • Cortical involvement in early MS is reflected in T1/PD quantitative MRI. • The changes are spatially heterogeneous. • Cortical damage goes beyond increased water content. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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