A Five-Gene Expression Signature Predicts Clinical Outcome of Ovarian Serous Cystadenocarcinoma.
Ovarian serous cystadenocarcinoma is a common malignant tumor of female genital organs. Treatment is generally less effective as patients are usually diagnosed in the late stage. Therefore, a well-designed prognostic marker provides valuable data for optimizing therapy. In this study, we analyzed 30...
| Publicado en: | BioMed Research International Vol. 2016; pp. 1 - 7 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
7/5/2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=116611451&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 116611451 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 7/5/2016 vid: 2016 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 116611451 116611451 116611451 10.1155/2016/6945304 116611451 ppf: 1 ppct: 6 formats: fmt: @attributes: type: P tig: atl: A Five-Gene Expression Signature Predicts Clinical Outcome of Ovarian Serous Cystadenocarcinoma. aug: au: Liu, Li-Wei Zhang, Qiuhao Guo, Wenna Qian, Kun Wang, Qiang affil: State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, China sug: subj: Adenocarcinoma Familial and Genetic Ovarian Neoplasms Familial and Genetic Gene Expression Adenocarcinoma Classification Ovarian Neoplasms Prognosis Adenocarcinoma Prognosis Human Female RNA Analysis Sequence Analysis Risk Assessment Cox Proportional Hazards Model Time Factors Kaplan-Meier Estimator ROC Curve Sensitivity and Specificity Ovarian Neoplasms Diagnosis Adenocarcinoma Diagnosis Ovarian Neoplasms Therapy Adenocarcinoma Therapy Adult Middle Age Aged Aged, 80 and Over Data Analysis Software Descriptive Statistics P-Value Confidence Intervals Funding Source Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Female ab: Ovarian serous cystadenocarcinoma is a common malignant tumor of female genital organs. Treatment is generally less effective as patients are usually diagnosed in the late stage. Therefore, a well-designed prognostic marker provides valuable data for optimizing therapy. In this study, we analyzed 303 samples of ovarian serous cystadenocarcinoma and the corresponding RNA-seq data. We observed the correlation between gene expression and patients’ survival and eventually established a risk assessment model of five factors using Cox proportional hazards regression analysis. We found that the survival time in high-risk patients was significantly shorter than in low-risk patients in both training and testing sets after Kaplan-Meier analysis. The AUROC value was 0.67 when predicting the survival time in testing set, which indicates a relatively high specificity and sensitivity. The results suggest diagnostic and therapeutic applications of our five-gene model for ovarian serous cystadenocarcinoma. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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