Impact of MammaPrint on Clinical Decision-Making in South African Patients with Early-Stage Breast Cancer.
The aim of the study was to evaluate the impact of MammaPrint on treatment decision-making in patients with breast cancer. Clinicopathologic information of all breast cancer patients referred for MammaPrint testing in South Africa was collected from 2007 until 2014. A total of 107 patients (109 tumo...
| Publicado en: | Breast Journal Vol. 22; no. 4; pp. 442 - 447 |
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| Autores principales: | , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Jul/Aug2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=116618962&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 116618962 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1075122X ET6 jtl: Breast Journal issn: 1075122X maglogo: Y pubinfo: dt: Jul/Aug2016 vid: 22 iid: 4 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 116618962 116618962 116618962 10.1111/tbj.12605 116618962 ppf: 442 ppct: 5 formats: fmt: @attributes: type: P tig: atl: Impact of MammaPrint on Clinical Decision-Making in South African Patients with Early-Stage Breast Cancer. aug: au: Pohl, Heinrich Kotze, Maritha J. Grant, Kathleen A. Merwe, Lize Pienaar, Fredrieka M. Apffelstaedt, Justus P. Myburgh, Ettienne J. affil: Department of Surgery, University of Stellenbosch, Tygerberg South Africa sug: subj: Decision Making, Patient Cancer Patients South Africa Breast Neoplasms Drug Therapy Gene Expression Profiling Methods South Africa Human Female Logistic Regression Adult Middle Age Confidence Intervals Odds Ratio Descriptive Statistics Data Analysis Software P-Value Eligibility Determination Chemotherapy, Adjuvant Interrater Reliability Algorithms Funding Source Oncogenes Breast Neoplasms Classification Adult: 19-44 years Middle Aged: 45-64 years Female ab: The aim of the study was to evaluate the impact of MammaPrint on treatment decision-making in patients with breast cancer. Clinicopathologic information of all breast cancer patients referred for MammaPrint testing in South Africa was collected from 2007 until 2014. A total of 107 patients (109 tumors) with estrogen receptor/progesterone receptor positive and human epidermal growth factor receptor-2 negative tumors were selected with tumors ≥10 mm, or when 1-3 nodes were involved without extra-nodal extension. None of the clinical indicators correlated significantly with the MammaPrint risk classification, which changed the decision for adjuvant chemotherapy in 52% of patients. Of 60 patients who were clinically high risk, 62% had a low-risk MammaPrint result and of the 47 clinically low -risk patients 40% had a high-risk MammaPrint result. This study indicates that MammaPrint could reduce the need for adjuvant chemotherapy by 17% using the selection criteria stipulated. The significant impact on treatment decisions confirmed the clinical utility of MammaPrint independent of standard clinicopathologic risk factors as supported by long-term clinical outcome studies. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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