Pharmacokinetics study of mazindol in plasma, oral fluid, and urine of volunteers.
Purpose: There are no pharmacokinetics studies in oral fluid reported in the literature, as well as there are no data on correlation of drug levels in plasma, urine, and oral fluid in order to propose alternative matrices to monitor the use of mazindol by drivers. The present work aimed to study, pr...
| Publicado en: | European Journal of Clinical Pharmacology Vol. 72; no. 8; pp. 945 - 952 |
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| Autores principales: | , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Aug2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=116775255&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 116775255 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00316970 NP9 jtl: European Journal of Clinical Pharmacology issn: 00316970 maglogo: N pubinfo: dt: Aug2016 vid: 72 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 116775255 116775255 116775255 10.1007/s00228-016-2055-8 116775255 ppf: 945 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Pharmacokinetics study of mazindol in plasma, oral fluid, and urine of volunteers. aug: au: Oliveira, Marcella Ferreira, Pâmela Carlos, Graciela Salazar, Fernanda Bergold, Ana Pechansky, Flavio Limberger, Renata Fröehlich, Pedro affil: Programa de Pós Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do sul, Avenida Ipiranga, 2752, Santana Porto Alegre CEP: 90610-000 Brazil sug: subj: Central Nervous System Stimulants Pharmacokinetics Central Nervous System Stimulants Blood Central Nervous System Stimulants Urine Saliva Analysis Central Nervous System Stimulants Metabolism Human Male Chromatography, Liquid Mass Spectrometry Outpatients Male ab: Purpose: There are no pharmacokinetics studies in oral fluid reported in the literature, as well as there are no data on correlation of drug levels in plasma, urine, and oral fluid in order to propose alternative matrices to monitor the use of mazindol by drivers. The present work aimed to study, preliminarily, mazindol's pharmacokinetics in plasma and oral fluid, as well as investigate the correlation of drug levels in urine, plasma, and oral fluid. Method: Blood, urine, and oral fluid samples from seven healthy male volunteers were collected at 0, 1, 2, 4, 5, 6, 8, 10, and 24 h after administration of tablets of 2 mg mazindol and analyzed by a previously validated method by LC-MS with liquid-liquid extraction. Levels of the drug found were higher in plasma when compared with oral fluid and higher in urine in relation to plasma. The study of the mazindol's pharmacokinetics showed that the most suitable model to describe the variation of the concentration over time is the compartment open model with absorption and elimination following the first-order kinetics, and confirming literature data, drug is metabolized, being the major metabolite detected, but not quantified. Conclusion: It was not found a good correlation between the concentrations of mazindol in urine and plasma, but between plasma and oral fluid, there was a good correlation, suggesting this as an alternative matrix to plasma. However, studies involving more subjects are needed. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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