Pediatric combined liver-kidney transplantation: a single-center experience of 18 cases.
Background: Experience in combined liver-kidney transplantation (CLKT) in children is limited. Methods: We conducted a retrospective study of all pediatric CLKTs performed at our medical institution between 1992 and 2013. Results: We identified 18 pediatric patients (9 girls) who had undergone CLKT...
| Publicado en: | Pediatric Nephrology Vol. 31; no. 9; pp. 1517 - 1530 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Sep2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=116791690&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 116791690 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0931041X EF1 jtl: Pediatric Nephrology issn: 0931041X maglogo: N pubinfo: dt: Sep2016 vid: 31 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 116791690 116791690 116791690 10.1007/s00467-016-3324-6 116791690 ppf: 1517 ppct: 13 formats: fmt: @attributes: type: P tig: atl: Pediatric combined liver-kidney transplantation: a single-center experience of 18 cases. aug: au: Duclaux-Loras, Rémi Bacchetta, Justine Berthiller, Julien Rivet, Christine Demède, Delphine Javouhey, Etienne Dubois, Rémi Dijoud, Frédérique Lachaux, Alain Badet, Lionel Boillot, Olivier Cochat, Pierre affil: Information Médicale Evaluation Recherche, Hospices Civils de Lyon, Lyon France sug: subj: Child Health Liver Transplantation Evaluation Kidney Transplantation Evaluation Outcomes (Health Care) Human Retrospective Design Female Male Descriptive Statistics Child, Preschool Child Adolescence Survival Analysis Glomerular Filtration Rate Oxalic Acids Urine Creatinine Urine Metabolism, Inborn Errors Complications Kidney Failure, Chronic Complications Child, Preschool: 2-5 years Child: 6-12 years Adolescent: 13-18 years Female Male ab: Background: Experience in combined liver-kidney transplantation (CLKT) in children is limited. Methods: We conducted a retrospective study of all pediatric CLKTs performed at our medical institution between 1992 and 2013. Results: We identified 18 pediatric patients (9 girls) who had undergone CLKT at our institution during the study period. The median age [range] and body weight [range] of this patient group was 3.6 [1.0-18.6] years and 13 [10-40] kg, respectively; 11 patients weighed <15 kg at the time of CLKT. Indications for CLKT were primary hyperoxaluria (PH1; n = 14), association of hepatic fibrosis and end-stage renal disease ( n = 3) and methylmalonic acidemia ( n = 1). In the early postoperative period, eight patients required dialysis. Median stay in the pediatric intensive care unit was 10 [6-29] days. One patient died from cardiovascular disease 10 years after CLKT. There were no liver graft losses despite six acute liver rejection episodes, whereas four kidney grafts were lost. At last follow-up (6 [0.5-21] years) for patients with a functioning renal graft, the glomerular filtration rate was 71 [26-146] mL/min/1.73 m. In PH1 patients, urine oxalate normalized in six patients within 3 years after CLKT, but three patients still presented with elevated oxaluria at 1, 2 and 3 years after CLKT. Conclusions: Pediatric CLKT provides encouraging results in the long term, even in the youngest patients. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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