H. pylori infection is related to mitochondrial microsatellite instability in gastric carcinogenesis.
Background: To assess the correlation of H. pylori infection with mitochondrial microsatellite instability (mtMSI) and IL-8 in gastric carcinogenesis. Methods: H. pylori infection was evaluated through histology and a urease breath test; mtMSI was measured using PCR-single strand conformation polymo...
| Publicado en: | Infectious Agents & Cancer Vol. 11; pp. 1 - 9 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
BioMed Central
7/12/2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=116829291&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 116829291 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 17509378 38MO jtl: Infectious Agents & Cancer issn: 17509378 maglogo: N pubinfo: dt: 7/12/2016 vid: 11 pid: 24147 pub: BioMed Central artinfo: ui: 116829291 116829291 116829291 10.1186/s13027-016-0078-5 116829291 ppf: 1 ppct: 8 formats: tig: atl: H. pylori infection is related to mitochondrial microsatellite instability in gastric carcinogenesis. aug: au: Xianlong Ling Haoxiang Zhang Caifei Shen Wu Yan Pu Wang Ji Feng Zhihong Peng Guiyong Peng Wensheng Chen Dianchun Fang affil: Department of Gastroenterology, Southwest Hospital, Third Military Medica University, Chongqing 400038, China sug: subj: Helicobacter Pylori Stomach Neoplasms Role Playing Breath Tests Infection Neoplasm Staging Spearman's Rank Correlation Coefficient Study Design Sampling Methods Sensitivity and Specificity ab: Background: To assess the correlation of H. pylori infection with mitochondrial microsatellite instability (mtMSI) and IL-8 in gastric carcinogenesis. Methods: H. pylori infection was evaluated through histology and a urease breath test; mtMSI was measured using PCR-single strand conformation polymorphism (PCR-SSCP); IL-8 was analyzed with ELISA methods. Results: The detection rate of mtMSI was significantly higher in specimens with H. pylori infection than in those without H. pylori infection (P < 0.05). The levels of IL-8 were significantly higher in specimens with mtMSI than in those without mtMSI (P < 0.01 ). An association of mtMSI with the intestinal histological type was found (P< 0.05). Increased IL-8 levels induced by H. pylori were related to the invasion, lymphnode spreading and clinical stage of gastric cancer (P < 0.05). Conclusions: H. pylori infection is related to mitochondrial microsatellite instability in the early steps of gastric cancer development. IL-8 may play a role in the development of mtMSI induced by H. pylori. Our results support a role for mtMSI in different mechanisms of gastric carcinogenesis. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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