A case report of successful treatment of pyoderma gangrenosum in a patient with autoimmune hepatitis, and review of the literature.
Background: Pyoderma Gangrenosum (PG) is a cutaneous condition, its diagnosis suggested by the presence of a painful cutaneous ulcer showing rapid progression. Pyoderma gangrenosum is associated with a concomitant systemic disease in 50 to 70 % of cases, including inflammatory bowel disease (IBD), r...
| Publicado en: | BMC Gastroenterology Vol. 15; no. 1; pp. 149 - 150 |
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| Autores principales: | , , , |
| Formato: | case study review Journal Article |
| Publicado: |
BioMed Central
2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=116837755&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 116837755 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1471230X 1CHO jtl: BMC Gastroenterology issn: 1471230X maglogo: N pubinfo: dt: 2015 vid: 15 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 116837755 116837755 NLM26502871 116837755 10.1186/s12876-015-0376-1 NLM26502871 PMC4624371 116837755 ppf: 149 ppct: 1 formats: tig: atl: A case report of successful treatment of pyoderma gangrenosum in a patient with autoimmune hepatitis, and review of the literature. aug: au: Androutsakos, Theodoros Stamopoulos, Paraskevas Aroni, Kiriaki Hatzis, Gregorios affil: Pathophysiology Department, Laiko General Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece sug: subj: Dermatologic Agents Therapeutic Use Pyoderma Gangrenosum Drug Therapy Hepatitis, Autoimmune Complications Antiinflammatory Agents Therapeutic Use Female Methotrexate Therapeutic Use Pyoderma Gangrenosum Etiology Young Adult Cyclosporine Therapeutic Use Prednisolone Therapeutic Use Drug Therapy, Combination Arthritis Impact Measurement Scales Female ab: Background: Pyoderma Gangrenosum (PG) is a cutaneous condition, its diagnosis suggested by the presence of a painful cutaneous ulcer showing rapid progression. Pyoderma gangrenosum is associated with a concomitant systemic disease in 50 to 70 % of cases, including inflammatory bowel disease (IBD), rheumatoid arthritis, and lymphoproliferative disorders. Although PG has also been reported with viral hepatitis, it is rarely associated with autoimmune hepatitis.Case Presentation: A 19-year-old Caucasian female, with a prior diagnosis of autoimmune hepatitis (AIH) in remission, presented with bilateral lower limb ulcers 4 years after the diagnosis of AIH. She was diagnosed with PG and treated with high-dose prednisolone, methotrexate and cyclosporine. One year later she was well, the ulcers completely healed, and with the autoimmune hepatitis still in remission.Conclusion: We report a case of autoimmune hepatitis and the subsequent, rarely occurring, extra-hepatic onset of pyoderma gangrenosum, with the AIH in remission, strengthening the association between the two conditions. Since both the AIH and the PG can present serious diagnostic challenges, thus delaying vital therapy, it is important that the development of either prompts us to consider the possibility of the other developing in the future or if already present facilitate its diagnosis, such considerations making the case for a systematic follow up. pubtype: Academic Journal doctype: case study review Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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