Accurate analysis and visualization of cardiac (11)C-PIB uptake in amyloidosis with semiautomatic software.
Background: (11)C-PIB PET is a promising non-invasive diagnostic tool for cardiac amyloidosis. Semiautomatic analysis of PET data is now available but it is not known how accurate these methods are for amyloid imaging. The aim of this study was to evaluate the feasibility of one semiautomatic softwa...
| Publicado en: | Journal of Nuclear Cardiology Vol. 23; no. 4; pp. 741 - 751 |
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| Autores principales: | , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Elsevier B.V.
Aug2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=116935106&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 116935106 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10713581 1YCL jtl: Journal of Nuclear Cardiology issn: 10713581 maglogo: N pubinfo: dt: Aug2016 vid: 23 iid: 4 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 116935106 116935106 NLM26173894 116935106 10.1007/s12350-015-0149-9 NLM26173894 116935106 ppf: 741 ppct: 10 formats: tig: atl: Accurate analysis and visualization of cardiac (11)C-PIB uptake in amyloidosis with semiautomatic software. aug: au: Kero, Tanja Lindsjö, Lars Sörensen, Jens Lubberink, Mark Lindsjö, Lars Sörensen, Jens affil: Department of Nuclear Medicine & PET, Uppsala University, Uppsala Sweden sug: subj: Tomography, Emission-Computed Methods Heart Failure Metabolism Thiazoles Pharmacokinetics Amyloidosis Metabolism Myocardium Metabolism Amyloidosis Image Interpretation, Computer Assisted Methods Female Observer Bias Middle Age Heart Heart Failure Aged Sensitivity and Specificity Information Science Methods Radiopharmaceuticals Pharmacokinetics Image Enhancement Methods Reproducibility of Results Male Human Middle Aged: 45-64 years Aged: 65+ years Female Male ab: Background: (11)C-PIB PET is a promising non-invasive diagnostic tool for cardiac amyloidosis. Semiautomatic analysis of PET data is now available but it is not known how accurate these methods are for amyloid imaging. The aim of this study was to evaluate the feasibility of one semiautomatic software tool for analysis and visualization of (11)C-PIB left ventricular retention index (RI) in cardiac amyloidosis.Methods and Results: Patients with systemic amyloidosis and cardiac involvement (n = 10) and healthy controls (n = 5) were investigated with dynamic (11)C-PIB PET. Two observers analyzed the PET studies with semiautomatic software to calculate the left ventricular RI of (11)C-PIB and to create parametric images. The mean RI at 15-25 min from the semiautomatic analysis was compared with RI based on manual analysis and showed comparable values (0.056 vs 0.054 min(-1) for amyloidosis patients and 0.024 vs 0.025 min(-1) in healthy controls; P = .78) and the correlation was excellent (r = 0.98). Inter-reader reproducibility also was excellent (intraclass correlation coefficient, ICC > 0.98). Parametric polarmaps and histograms made visual separation of amyloidosis patients and healthy controls fast and simple.Conclusion: Accurate semiautomatic analysis of cardiac (11)C-PIB RI in amyloidosis patients is feasible. Parametric polarmaps and histograms make visual interpretation fast and simple. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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