Differences in Brain Metabolic Impairment between Chronic Mild/Moderate TBI Patients with and without Visible Brain Lesions Based on MRI.
Introduction. Many patients with mild/moderate traumatic brain injury (m/mTBI) in the chronic stage suffer from executive brain function impairment. Analyzing brain metabolism is important for elucidating the pathological mechanisms associated with their symptoms. This study aimed to determine the d...
| Publicado en: | BioMed Research International Vol. 2016; pp. 1 - 9 |
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| Autores principales: | , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
7/26/2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=117015889&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 117015889 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 7/26/2016 vid: 2016 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 117015889 117015889 117015889 10.1155/2016/3794029 117015889 ppf: 1 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Differences in Brain Metabolic Impairment between Chronic Mild/Moderate TBI Patients with and without Visible Brain Lesions Based on MRI. aug: au: Ito, Keiichi Asano, Yoshitaka Ikegame, Yuka Shinoda, Jun affil: Department of Clinical Brain Sciences, Gifu University Graduate School of Medicine, Gifu, Gifu 501-1194, Japan sug: subj: Magnetic Resonance Imaging Brain Metabolism Executive Function Brain Injuries Complications Glucose Metabolism Brain Injuries Classification Human Accidents, Traffic Tomography, Emission-Computed Fludeoxyglucose F 18 Cognition Evaluation Frontal Lobe Metabolism Limbic System Metabolism Thalamus Metabolism Adult Middle Age Japan Glasgow Coma Scale Scales Male Female Descriptive Statistics P-Value Data Analysis Software Paired T-Tests Regression Parietal Lobe Metabolism Occipital Lobe Metabolism Cognition Disorders Pathology Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Introduction. Many patients with mild/moderate traumatic brain injury (m/mTBI) in the chronic stage suffer from executive brain function impairment. Analyzing brain metabolism is important for elucidating the pathological mechanisms associated with their symptoms. This study aimed to determine the differences in brain glucose metabolism between m/mTBI patients with and without visible traumatic brain lesions based on MRI. Methods. Ninety patients with chronic m/mTBI due to traffic accidents were enrolled and divided into two groups based on their MRI findings. Group A comprised 50 patients with visible lesions. Group B comprised 40 patients without visible lesions. Patients underwent FDG-PET scans following cognitive tests. FDG-PET images were analyzed using voxel-by-voxel univariate statistical tests. Results. There were no significant differences in the cognitive tests between Group A and Group B. Based on FDG-PET findings, brain metabolism significantly decreased in the orbital gyrus, cingulate gyrus, and medial thalamus but increased in the parietal and occipital convexity in Group A compared with that in the control. Compared with the control, patients in Group B exhibited no significant changes. Conclusions. These results suggest that different pathological mechanisms may underlie cognitive impairment in m/mTBI patients with and without organic brain damage. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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