Variability of FeNO in healthy subjects at 2240 meters above sea level.
Fraction of exhaled nitric oxide (FeNO) is a marker of eosinophilic airway inflammation. Altitude above sea level can affect measurements of this index, but there is only limited information regarding the diurnal variation (ante meridiem vs. post meridiem) and reproducibility of FeNO on consecutive...
| Publicado en: | Journal of Clinical Monitoring & Computing Vol. 30; no. 4; pp. 445 - 450 |
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| Autores principales: | , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Aug2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=117018119&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 117018119 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13871307 OHC jtl: Journal of Clinical Monitoring & Computing issn: 13871307 maglogo: N pubinfo: dt: Aug2016 vid: 30 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 117018119 117018119 NLM26174797 117018119 10.1007/s10877-015-9737-0 NLM26174797 117018119 ppf: 445 ppct: 5 formats: fmt: @attributes: type: P tig: atl: Variability of FeNO in healthy subjects at 2240 meters above sea level. aug: au: Gochicoa-Rangel, Laura Rojas-Cisneros, Fermín Miguel-Reyes, José Guerrero-Zúñiga, Selene Mora-Romero, Uri Maldonado-Mortera, Ana Torre-Bouscoulet, Luis Rojas-Cisneros, Fermín Miguel-Reyes, José Luis Guerrero-Zúñiga, Selene Maldonado-Mortera, Ana Karen affil: Departamento de Fisiología Respiratoria, Instituto Nacional de Enfermedades Respiratorias 'Ismael Cosío Villegas', Calzada de Tlalpan 4502, Colonia Sección XVI, Tlalpan C.P. 14080 Mexico City Mexico sug: subj: Altitude Nitric Oxide Metabolism Male Eosinophilia Metabolism Female Reproducibility of Results Cross Sectional Studies Asthma Metabolism Circadian Rhythm Adult Research Subjects Expiration Young Adult Human Adult: 19-44 years Male Female ab: Fraction of exhaled nitric oxide (FeNO) is a marker of eosinophilic airway inflammation. Altitude above sea level can affect measurements of this index, but there is only limited information regarding the diurnal variation (ante meridiem vs. post meridiem) and reproducibility of FeNO on consecutive days at moderate altitudes. To evaluate the diurnal variability of FeNO and assess its reproducibility over five consecutive days in healthy individuals living at 2240 m, and to compare the FeNO readings taken with two different analyzers. Healthy non-smoking adults were measured using NIOX MINO(®) or NOA 280i(®) devices. One group (n = 10) had readings taken morning and afternoon for five consecutive days with the NIOX MINO(®) equipment; while the second group (n = 17) was measured on only one morning but by both the electrochemical analyzer (NIOX MINO(®)) and the chemiluminescence method (NOA 280i(®)). The study group consisted of 27 subjects aged 28.7 ± 6 years. Morning and afternoon FeNO measurements were 15.2 ± 7.5 ppb and 15.2 ± 7.9 ppb (p = 0.9), respectively. The coefficient of variation (CV) of these measurements (a.m. vs. p.m.) was 10.7 %, and the coefficient of repeatability (CR), 4.2 ppb. The concordance correlation coefficient (CCC) between the two measures (morning vs. afternoon) was 0.91. The CV and CR of the five morning readings were 15.4 % and 4.3 ppb, respectively; while those of the five afternoon measures were 13.6 % and 3.5 ppb, respectively. The CCC between the NIOX MINO(®) equipment and the NOA-280i(®) device was 0.8, with 95 % limits of agreement of -8.35 to 0.29 ppb. In adults living at 2240 m above sea level, FeNO measurements show minimal diurnal variation, and readings are reproducible (<15 %) over a period of at least five consecutive days; however, the FeNO measurements obtained with the NIOX MINO(®) and NOA 280i(®) devices are not interchangeable due to the wide limits of agreement recorded. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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