Frequency domain analysis of cerebral near infrared spectroscopy signals during application of an impedance threshold device in spontaneously ventilating volunteers.

Currently available near infrared spectroscopy (NIRS) devices are unable to discriminate between arterial and venous blood, a potential source of artifact. The purpose of this study was to test the hypothesis that oscillations in NIR signals at the respiratory and cardiac frequency could be attribut...

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Publicado en:Journal of Clinical Monitoring & Computing Vol. 30; no. 4; pp. 389 - 399
Autores principales: Colquhoun, Douglas, Naden, Kimberly, Thiele, Robert, Colquhoun, Douglas A, Thiele, Robert H
Formato: equations & formulas research tables/charts tracings Journal Article
Publicado: Springer Nature Aug2016
Acceso en línea:Ver este registro en EBSCOhost
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      pub: Springer Nature
      place: New York, New York
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        atl: Frequency domain analysis of cerebral near infrared spectroscopy signals during application of an impedance threshold device in spontaneously ventilating volunteers.
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        au:
          Colquhoun, Douglas
          Naden, Kimberly
          Thiele, Robert
          Colquhoun, Douglas A
          Thiele, Robert H
        affil: Department of Anesthesiology, University of Virginia School of Medicine, Charlottesville 22908-0710 USA
      sug:
        subj:
          Spectroscopy, Near-Infrared Methods
          Respiration
          Male
          Blood Pressure
          Blood Flow Velocity
          Research Subjects
          Oximetry Methods
          Aged
          Electric Impedance
          Perfusion
          Adult
          Oxygen Blood
          Artifacts
          Oxygen Consumption
          Middle Age
          Oxygen
          Algorithms
          Pressure
          Young Adult
          Female
          Adolescence
          Human
          Aged: 65+ years
          Adult: 19-44 years
          Middle Aged: 45-64 years
          Adolescent: 13-18 years
          Male
          Female
      ab: Currently available near infrared spectroscopy (NIRS) devices are unable to discriminate between arterial and venous blood, a potential source of artifact. The purpose of this study was to test the hypothesis that oscillations in NIR signals at the respiratory and cardiac frequency could be attributed to venous and arterial blood, respectively, and thereby isolated. After written informed consent was obtained, a two-wavelength NIRS device was placed over the left frontal cortex in 20 volunteers. After 5 min of unimpeded spontaneous ventilation, an impedance threshold device (ITD, average resistance-7 cm H2O) was applied and an additional two minutes of data recorded. Tissue saturation (StO2) calculated at the ventilatory and cardiac frequencies was compared to non-pulsatile StO2, before and after application of the ITD using spectral peak and power algorithms. The ITD increased non-pulsatile cerebral saturation by 3.6 %. The ITD had no discernable effect on pulsatile estimates of StO2 at either the ventilatory or cardiac frequencies. StO2 estimated at the NIRS spectral peak from 0.75 to 1.75 Hz was 24 % higher than non-pulsatile StO2 (p = 0.0013). There were no other significant differences between pulsatile and non-pulsatile algorithms in the estimation of StO2. In 64 % of cases, both the low (ventilator) and high (cardiac) frequency estimates of StO2 were either both larger or both smaller than non-pulsatile StO2, suggesting that they were interrogating the same vascular bed. Frequency domain analysis cannot reliably separate NIRS waveforms into arterial and venous components.
      pubtype: Academic Journal
      doctype:
        equations & formulas
        research
        tables/charts
        tracings
        Journal Article
      ougenre: Article
    language: English
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