Breast MRI contrast enhancement kinetics of normal parenchyma correlate with presence of breast cancer.
Background: We investigated dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) contrast enhancement kinetic variables quantified from normal breast parenchyma for association with presence of breast cancer, in a case-control study.Methods: Under a Health Insurance Portability and Account...
| Published in: | Breast Cancer Research Vol. 18; pp. 1 - 11 |
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| Main Authors: | , , , , , , , , |
| Format: | research Journal Article |
| Published: |
BioMed Central
7/22/2016
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=117027034&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 117027034 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14655411 8UYJ jtl: Breast Cancer Research issn: 14655411 maglogo: N pubinfo: dt: 7/22/2016 vid: 18 pid: 24147 pub: BioMed Central artinfo: ui: 117027034 117027034 NLM27449059 117027034 10.1186/s13058-016-0734-0 NLM27449059 PMC4957890 117027034 ppf: 1 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Breast MRI contrast enhancement kinetics of normal parenchyma correlate with presence of breast cancer. aug: au: Shandong Wu Berg, Wendie A. Zuley, Margarita L. Kurland, Brenda F. Jankowitz, Rachel C. Nishikawa, Robert Gur, David Sumkin, Jules H. Wu, Shandong affil: Department of Radiology, University of Pittsburgh, 4200 Fifth Ave, Pittsburgh, PA 15260, USA sug: subj: Breast Neoplasms Image Enhancement Breast Neoplasms Pathology Magnetic Resonance Imaging Methods Contrast Media Adult Reproducibility of Results Female Risk Factors Retrospective Design Case Control Studies Middle Age Image Processing, Computer Assisted Pharmacokinetics Adult: 19-44 years Middle Aged: 45-64 years Female ab: Background: We investigated dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) contrast enhancement kinetic variables quantified from normal breast parenchyma for association with presence of breast cancer, in a case-control study.Methods: Under a Health Insurance Portability and Accountability Act compliant and Institutional Review Board-approved protocol, DCE-MRI scans of the contralateral breasts of 51 patients with cancer and 51 controls (matched by age and year of MRI) with biopsy-proven benign lesions were retrospectively analyzed. Applying fully automated computer algorithms on pre-contrast and multiple post-contrast MR sequences, two contrast enhancement kinetic variables, wash-in slope and signal enhancement ratio, were quantified from normal parenchyma of the contralateral breasts of both patients with cancer and controls. Conditional logistic regression was employed to assess association between these two measures and presence of breast cancer, with adjustment for other imaging factors including mammographic breast density and MRI background parenchymal enhancement (BPE). The area under the receiver operating characteristic curve (AUC) was used to assess the ability of the kinetic measures to distinguish patients with cancer from controls.Results: When both kinetic measures were included in conditional logistic regression analysis, the odds ratio for breast cancer was 1.7 (95 % CI 1.1, 2.8; p = 0.017) for wash-in slope variance and 3.5 (95 % CI 1.2, 9.9; p = 0.019) for signal enhancement ratio volume, respectively. These odds ratios were similar on respective univariate analysis, and remained significant after adjustment for menopausal status, family history, and mammographic density. While percent BPE was associated with an odds ratio of 3.1 (95 % CI 1.2, 7.9; p = 0.018), in multivariable analysis of the three measures, percent BPE was non-significant (p = 0.897) and the two kinetics measures remained significant. For the differentiation of patients with cancer and controls, the unadjusted AUC was 0.71 using a combination of the two measures, which significantly (p = 0.005) outperformed either measure alone (AUC = 0.65 for wash-in slope variance and 0.63 for signal enhancement ratio volume).Conclusions: Kinetic measures of wash-in slope and signal enhancement ratio quantified from normal parenchyma in DCE-MRI are jointly associated with presence of breast cancer, even after adjustment for mammographic density and BPE. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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