Opioids for management of episodic breathlessness or dyspnea in patients with advanced disease.
Background: Episodic breathlessness (EB) or dyspnea is a common symptom with a very negative impact on the quality of life of patients with cancer and with non-oncological advanced diseases, mainly cardiorespiratory and neurological.Objective: The purpose of this non-systematic review is to ascertai...
| Published in: | Supportive Care in Cancer Vol. 24; no. 9; pp. 4045 - 4056 |
|---|---|
| Main Authors: | , , , , , , |
| Format: | research systematic review tables/charts Journal Article |
| Published: |
Springer Nature
Sep2016
|
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=117109099&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 117109099 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09414355 O1J jtl: Supportive Care in Cancer issn: 09414355 maglogo: N pubinfo: dt: Sep2016 vid: 24 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 117109099 117109099 NLM27334130 117109099 10.1007/s00520-016-3316-x NLM27334130 117109099 ppf: 4045 ppct: 11 formats: fmt: @attributes: type: P tig: atl: Opioids for management of episodic breathlessness or dyspnea in patients with advanced disease. aug: au: Cabezón-Gutiérrez, Luis Khosravi-Shahi, Parham Custodio-Cabello, Sara Muñiz-González, Francisco Cano-Aguirre, Maria Alonso-Viteri, Soledad Cabezón-Gutiérrez, Luis Muñiz-González, Francisco Cano-Aguirre, Maria Del Puerto affil: Medical Oncology Department, Hospital Universitario de Torrejón, Mateo Inurria Street s/n CP 28850 Torrejón de Ardoz, Madrid Spain sug: subj: Analgesics, Opioid Therapeutic Use Neoplasms Physiopathology Dyspnea Drug Therapy Neoplasms Drug Therapy Prospective Studies Human Quality of Life Systematic Review ab: Background: Episodic breathlessness (EB) or dyspnea is a common symptom with a very negative impact on the quality of life of patients with cancer and with non-oncological advanced diseases, mainly cardiorespiratory and neurological.Objective: The purpose of this non-systematic review is to ascertain the role played by opioids in the management of episodic breathlessness.Methods: A non-systematic literature review was done in the databases MEDLINE, COCHRANE, and DATABASE, and articles of greater scientific rigor, mainly reviews or prospective studies/randomized clinical trials published to date (August 2015), were selected. Terms used in the search included episodic breathlessness, acute breathlessness, episodic dyspnea, opioids, morphine, fentanyl, oxycodone, and breakthrough dyspnea.Conclusions: Although the pathophysiology and mechanism of action of opioids for management of breathlessness, and specifically EB, are not fully known, there is scientific evidence, and particularly great clinical evidence, of the benefit of this drug class for dyspnea management. It is important to differentiate hospitalized patients from outpatients because venous or subcutaneous access is easier in hospitalized patients, but use of transmucosal fentanyl, especially in faster formulations like intranasal application, opens up new possibilities to manage outpatients due to its fast onset of action. The main problem is the lack of data available and the multitude of unanswered questions about opioid type, administration route, safety, and dose titration. pubtype: Academic Journal doctype: research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|