Preoperative Peak Oxygen Uptake in Lung Cancer Subjects With Neoadjuvant Chemotherapy: A Cross-Sectional Study.
BACKGROUND: In non-small-cell lung cancer patients, high peak oxygen uptake (peak ...) predicts lower rates of postoperative complications and better long-term survival. Neoadjuvant chemotherapy (NAC) may negatively impact peak ... METHODS: Cardiopulmonary exercise testing (CPET) was performed in 34...
| Publicado en: | Respiratory Care Vol. 61; no. 8; pp. 1059 - 1067 |
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| Autores principales: | , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Mary Ann Liebert, Inc.
Aug2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=117140857&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 117140857 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00201324 4GG jtl: Respiratory Care issn: 00201324 maglogo: N pubinfo: dt: Aug2016 vid: 61 iid: 8 pid: 1365 pub: Mary Ann Liebert, Inc. place: New Rochelle, New York artinfo: ui: 117140857 117140857 117140857 10.4187/respcare.04299 117140857 ppf: 1059 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Preoperative Peak Oxygen Uptake in Lung Cancer Subjects With Neoadjuvant Chemotherapy: A Cross-Sectional Study. aug: au: Fresard, Isabelle Licker, Marc Adler, Dan Lovis, Alban Robert, John Karenovics, Wolfram Diaper, John affil: Division of Pulmonary Medicine, Geneva Faculty of Medicine, University Hospitals of Geneva, Geneva, Switzerland sug: subj: Neoadjuvant Therapy Carcinoma, Non-Small-Cell Lung Surgery Oxygen Consumption Human Cross Sectional Studies Exercise Test, Cardiopulmonary Multiple Linear Regression Confidence Intervals Switzerland Prospective Studies Respiratory Function Tests Male Female Adult Middle Age Aged Postoperative Complications Heart Rate Evaluation Aerobic Capacity Funding Source Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Male Female ab: BACKGROUND: In non-small-cell lung cancer patients, high peak oxygen uptake (peak ...) predicts lower rates of postoperative complications and better long-term survival. Neoadjuvant chemotherapy (NAC) may negatively impact peak ... METHODS: Cardiopulmonary exercise testing (CPET) was performed in 34 consecutive stage IIIA/IIIB non-small-cell lung cancer subjects scheduled for elective lung surgery. Using multivariate linear regression adjusted for potential confounders, we compared CPET results in subjects receiving or not receiving NAC (NAC+, n = 19; NAC-, n = 15). RESULTS: Adjusted peak ... was lower in NAC + compared with NAC- subjects (-5.3 mL/min/kg [95% CI -8.3 to -2.2], P = .01). Likewise, oxygen pulse, maximal work load, and ventilatory threshold were also lower in NAC+ subjects, whereas peak heart rate and breathing reserve were similar. NAC+ subjects presented lower values of diffusion capacity for carbon monoxide (DLCO) (P = .035) and hemoglobin concentrations (P < .001). DLCO was strongly correlated with peak ... (r² = 0.56). Adjustment for DLCO reduced the effect of NAC on peak ... without suppressing it. CONCLUSIONS: NAC was associated with lower preoperative peak ... in subjects with non-small-cell lung cancer. This lower aerobic fitness may result from NAC-induced reduction in pulmonary gas exchange or heart toxicity. Since lower fitness is linked to poorer outcome, the decision for NAC may have to be balanced with its possible toxicity. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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