A Gram-Negative Bacterial Secreted Protein Types Prediction Method Based on PSI-BLAST Profile.

Prediction of secreted protein types based solely on sequence data remains to be a challenging problem. In this study, we extract the long-range correlation information and linear correlation information from position-specific score matrix (PSSM). A total of 6800 features are extracted at 17 differe...

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Publicado en:BioMed Research International Vol. 2016; pp. 1 - 6
Autores principales: Ding, Shuyan, Zhang, Shengli
Formato: equations & formulas research tables/charts Journal Article
Publicado: Wiley-Blackwell 8/2/2016
Acceso en línea:Ver este registro en EBSCOhost
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      dt: 8/2/2016
      vid: 2016
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      pub: Wiley-Blackwell
      place: Malden, Massachusetts
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        10.1155/2016/3206741
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        atl: A Gram-Negative Bacterial Secreted Protein Types Prediction Method Based on PSI-BLAST Profile.
      aug:
        au:
          Ding, Shuyan
          Zhang, Shengli
        affil: Department of Sciences, Dalian Nationalities University, Dalian 116600, China
      sug:
        subj:
          Proteins
          Biological Markers
          Gram-Negative Bacterial Infections
          Secretions
          Human
          Factor Analysis
          Algorithms
          Sensitivity and Specificity
          Funding Source
      ab: Prediction of secreted protein types based solely on sequence data remains to be a challenging problem. In this study, we extract the long-range correlation information and linear correlation information from position-specific score matrix (PSSM). A total of 6800 features are extracted at 17 different gaps; then, 309 features are selected by a filter feature selection method based on the training set. To verify the performance of our method, jackknife and independent dataset tests are performed on the test set and the reported overall accuracies are 93.60% and 100%, respectively. Comparison of our results with the existing method shows that our method provides the favorable performance for secreted protein type prediction.
      pubtype: Academic Journal
      doctype:
        equations & formulas
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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