Diffusion-weighted imaging of hepatocellular carcinomas: a retrospective analysis of correlation between apparent diffusion coefficients and histological grade.
Purpose: To define correlations between the pathological grades of hepatocellular carcinomas (HCCs) and apparent diffusion coefficients (ADCs) derived using breath-holding diffusion-weighted imaging (BH-DWI). Methods: We retrospectively evaluated 94 patients (105 lesions) with pathologically proved...
| Publicado en: | Abdominal Radiology Vol. 41; no. 8; pp. 1539 - 1546 |
|---|---|
| Autores principales: | , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Aug2016
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=117170712&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 117170712 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 2366004X JT14 jtl: Abdominal Radiology issn: 2366004X maglogo: N pubinfo: dt: Aug2016 vid: 41 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 117170712 10.1007/s00261-016-0715-x 117170712 ppf: 1539 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Diffusion-weighted imaging of hepatocellular carcinomas: a retrospective analysis of correlation between apparent diffusion coefficients and histological grade. aug: au: Tang, Yanhua Wang, Haiyi Ma, Lu Zhang, Xiaojing Yu, Guo Li, Jie Ye, Huiyi affil: Department of Radiology , Chinese PLA General Hospital , Fuxing Road 28 Beijing China sug: ab: Purpose: To define correlations between the pathological grades of hepatocellular carcinomas (HCCs) and apparent diffusion coefficients (ADCs) derived using breath-holding diffusion-weighted imaging (BH-DWI). Methods: We retrospectively evaluated 94 patients (105 lesions) with pathologically proved HCC who underwent hepatic DWI on a 3.0-T MR platform. HCCs were divided into five groups: well-differentiated ( n = 10), well-to-moderately differentiated ( n = 11), moderately differentiated ( n = 51), moderately to poorly differentiated ( n = 20), and poorly differentiated ( n = 13) groups. The ADCs of carcinomas across different histological grades were compared by one-way analysis of variance. Spearman's rank correlation test was used to analyze correlations between the degree of histopathological differentiation and ADC. Results were corrected for multiple comparisons using the Bonferroni correction. Results: The BH technique yielded ADC values that differed significantly by the extent of differentiation ( F = 8.392, p < 0.001). A significant negative correlation was found between the extent of differentiation and ADCs ( r = −0.462, p < 0.001). The mean ADC values of poorly differentiated HCCs were significantly lower than the well-, well-to-moderately, moderately, and moderately to poorly differentiated HCCs ( p values were <0.001, <0.001, 0.003, and 0.031, respectively). Conclusion: ADC values obtained with BH-DWI may be of importance to non-invasively predict HCC tumor differentiation, and the extent of histological HCC differentiation was inversely correlated with ADC values. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|