Prospective estimation of mean axon diameter and extra-axonal space of the posterior limb of the internal capsule in patients with idiopathic normal pressure hydrocephalus before and after a lumboperitoneal shunt by using q-space diffusion MRI.
Objectives: To prospectively estimate the mean axon diameter (MAD) and extracellular space of the posterior limb of the internal capsule (PLIC) in patients with idiopathic normal pressure hydrocephalus (iNPH) before and after a lumboperitoneal (LP) shunting operation using q-space diffusion MRI anal...
| Publicado en: | European Radiology Vol. 26; no. 9; pp. 2992 - 2999 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Sep2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=117171306&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 117171306 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Sep2016 vid: 26 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 117171306 117171306 NLM26694062 10.1007/s00330-015-4162-9 NLM26694062 PMC4972860 117171306 ppf: 2992 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Prospective estimation of mean axon diameter and extra-axonal space of the posterior limb of the internal capsule in patients with idiopathic normal pressure hydrocephalus before and after a lumboperitoneal shunt by using q-space diffusion MRI. aug: au: Hori, Masaaki Kamiya, Kouhei Nakanishi, Atsushi Fukunaga, Issei Miyajima, Masakazu Nakajima, Madoka Suzuki, Michimasa Suzuki, Yuriko Irie, Ryusuke Kamagata, Koji Arai, Hajime Aoki, Shigeki affil: Department of Radiology , Juntendo University School of Medicine , 2-1-1 Hongo, Bunkyo-ku Tokyo 113-8421 Japan sug: subj: Hydrocephalus, Normal Pressure Magnetic Resonance Imaging Methods Nerve Fibers Neural Pathways Hydrocephalus, Normal Pressure Surgery Aged Female Male Prospective Studies Aged: 65+ years Female Male ab: Objectives: To prospectively estimate the mean axon diameter (MAD) and extracellular space of the posterior limb of the internal capsule (PLIC) in patients with idiopathic normal pressure hydrocephalus (iNPH) before and after a lumboperitoneal (LP) shunting operation using q-space diffusion MRI analysis.Methods: We studied 12 consecutive patients with iNPH and 12 controls at our institution. After conventional magnetic resonance imaging (MRI), q-space image (QSI) data were acquired with a 3-T MRI scanner. The MAD and extra-axonal space of the PLIC before and after LP shunting were calculated using two-component q-space imaging analyses; the before and after values were compared.Results: After LP shunt surgery, the extracellular space of the PLIC was significantly higher than that of the same patients before the operation (one-way analysis of variance (ANOVA) with Scheffé's post-hoc test, P = 0.024). No significant differences were observed in the PLIC axon diameters among normal controls or in patients before and after surgery.Conclusion: Increases in the root mean square displacement in the extra-axonal space of the PLIC in patients with iNPH after an LP shunt procedure are associated with the microstructural changes of white matter and subsequent abatement of patient symptoms.Key Points: • Q-space diffusion MRI provides information on microstructural changes in the corticospinal tract • Lumboperitoneal (LP) shunting operation is useful for idiopathic normal pressure hydrocephalus • Q-space measurement may be a biomarker for the effect of the LP shunt procedure. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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