Normal spectrum of pulmonary parametric response map to differentiate lung collapsibility: distribution of densitometric classifications in healthy adult volunteers.
Objectives: Pulmonary parametric response map (PRM) was proposed for quantitative densitometric phenotypization of chronic obstructive pulmonary disease. However, little is known about this technique in healthy subjects. The purpose of this study was to describe the normal spectrum of densitometric...
| Publicado en: | European Radiology Vol. 26; no. 9; pp. 3063 - 3071 |
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| Autores principales: | , , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Sep2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=117171329&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 117171329 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Sep2016 vid: 26 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 117171329 117171329 NLM26638165 117171329 10.1007/s00330-015-4133-1 NLM26638165 117171329 ppf: 3063 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Normal spectrum of pulmonary parametric response map to differentiate lung collapsibility: distribution of densitometric classifications in healthy adult volunteers. aug: au: Silva, Mario Nemec, Stefan Dufresne, Valerie Occhipinti, Mariaelena Heidinger, Benedikt Chamberlain, Ryan Bankier, Alexander Nemec, Stefan F Heidinger, Benedikt H Bankier, Alexander A affil: Department of Biomedical Imaging and Image-guided Therapy , Medical University of Vienna , Waehringer Guertel 18-20 A-1090 Vienna Austria sug: subj: Lung Anatomy and Histology Densitometry Female Aged Middle Age Male Pulmonary Atelectasis Pathology Emphysema Physiopathology Expiration Physiology Tomography, X-Ray Computed Methods Pulmonary Disease, Chronic Obstructive Physiopathology Emphysema Pathology Total Lung Capacity Physiology Respiratory Function Tests Adult Lung Physiology Pulmonary Atelectasis Physiopathology Research Subjects Pulmonary Disease, Chronic Obstructive Pathology Human Aged: 65+ years Middle Aged: 45-64 years Adult: 19-44 years Female Male ab: Objectives: Pulmonary parametric response map (PRM) was proposed for quantitative densitometric phenotypization of chronic obstructive pulmonary disease. However, little is known about this technique in healthy subjects. The purpose of this study was to describe the normal spectrum of densitometric classification of pulmonary PRM in a group of healthy adults.Methods: 15 healthy volunteers underwent spirometrically monitored chest CT at total lung capacity (TLC) and functional residual capacity (FRC). The paired CT scans were analyzed by PRM for voxel-by-voxel characterization of lung parenchyma according to 4 densitometric classifications: normal lung (TLC ≥ -950 HU, FRC ≥ -856 HU); expiratory low attenuation area (LAA) (TLC ≥ -950 HU, FRC < -856 HU); dual LAA (TLC<-950 HU, FRC < -856 HU); uncharacterized (TLC < -950 HU, FRC ≥ -856 HU).Results: PRM spectrum was 78 % ± 10 % normal lung, 20 % ± 8 % expiratory LAA, and 1 % ± 1 % dual LAA. PRM was similar between genders, there was moderate correlation between dual LAA and spirometrically assessed TLC (R = 0.531; p = 0.042), and between expiratory LAA and VolExp/Insp ratio (R = -0.572; p = 0.026).Conclusions: PRM reflects the predominance of normal lung parenchyma in a group of healthy volunteers. However, PRM also confirms the presence of physiological expiratory LAA seemingly related to air trapping and a minimal amount of dual LAA likely reflecting emphysema.Key Points: • Co-registration of inspiratory and expiratory computed tomography allows dual-phase densitometry. • Dual-phase co-registered densitometry reflects heterogeneous regional changes in lung function. • Quantification of lung in healthy subjects is needed to set reference values. • Expiratory low attenuation areas <30 % could be considered within normal range. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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