Generalized estimation of the ventilatory distribution from the multiple-breath nitrogen washout.
Background: This work presents a generalized technique to estimate pulmonary ventilation-to-volume (v/V) distributions using the multiple-breath nitrogen washout, in which both tidal volume (V T ) and the end-expiratory lung volume (EELV) are allowed to vary during the maneuver. In addition, the vol...
| Publicado en: | BioMedical Engineering OnLine Vol. 15; pp. 1 - 19 |
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| Autores principales: | , , , |
| Formato: | Journal Article |
| Publicado: |
BioMed Central
8/2/2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=117302177&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 117302177 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1475925X 1CGX jtl: BioMedical Engineering OnLine issn: 1475925X maglogo: N pubinfo: dt: 8/2/2016 vid: 15 pid: 24147 pub: BioMed Central artinfo: ui: 117302177 117302177 NLM27480332 10.1186/s12938-016-0213-y NLM27480332 PMC4970303 117302177 ppf: 1 ppct: 18 formats: tig: atl: Generalized estimation of the ventilatory distribution from the multiple-breath nitrogen washout. aug: au: Motta-Ribeiro, Gabriel Casulari Jandre, Frederico Caetano Wrigge, Hermann Giannella-Neto, Antonio affil: Pulmonary Engineering Laboratory, Biomedical Engineering Programme, COPPE, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil sug: subj: Nitrogen Metabolism Respiration Models, Biological Respiratory Airflow Tidal Volume Regression Clinical Assessment Tools Ferrans and Powers Quality of Life Index Scales ab: Background: This work presents a generalized technique to estimate pulmonary ventilation-to-volume (v/V) distributions using the multiple-breath nitrogen washout, in which both tidal volume (V T ) and the end-expiratory lung volume (EELV) are allowed to vary during the maneuver. In addition, the volume of the series dead space (v d ), unlike the classical model, is considered a common series unit connected to a set of parallel alveolar units.Methods: The numerical solution for simulated data, either error-free or with the N2 measurement contaminated with the addition of Gaussian random noise of 3 or 5 % standard deviation was tested under several conditions in a computational model constituted by 50 alveolar units with unimodal and bimodal distributions of v/V. Non-negative least squares regression with Tikhonov regularization was employed for parameter retrieval. The solution was obtained with either unconstrained or constrained (V T , EELV and v d ) conditions. The Tikhonov gain was fixed or estimated and a weighting matrix (WM) was considered. The quality of estimation was evaluated by the sum of the squared errors (SSE) (between reference and recovered distributions) and by the deviations of the first three moments calculated for both distributions. Additionally, a shape classification method was tested to identify the solution as unimodal or bimodal, by counting the number of shape agreements after 1000 repetitions.Results: The accuracy of the results showed a high dependence on the noise amplitude. The best algorithm for SSE and moments included the constrained and the WM solvers, whereas shape agreement improved without WM, resulting in 97.2 % for unimodal and 90.0 % for bimodal distributions in the highest noise condition.Conclusions: In conclusion this generalized method was able to identify v/V distributions from a lung model with a common series dead space even with variable V T . Although limitations remain in presence of experimental noise, appropriate combination of processing steps were also found to reduce estimation errors. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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