Sequential Versus Concomitant Therapy for Eradication of Helicobacter Pylori in Patients with Perforated Duodenal Ulcer: A Randomized Trial.
Objectives: Comparison of Helicobacter pylori eradication rates, side effects, compliance, cost, and ulcer recurrence of sequential therapy (ST) with that of concomitant therapy (CT) in patients with perforated duodenal ulcer following simple omental patch closure. Methods: Sixty-eight patients with...
| Publicado en: | Saudi Journal of Gastroenterology Vol. 22; no. 4; pp. 309 - 316 |
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| Autores principales: | , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wolters Kluwer India Pvt Ltd
Jul/Aug2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=117335294&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 117335294 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13193767 322P jtl: Saudi Journal of Gastroenterology issn: 13193767 maglogo: N pubinfo: dt: Jul/Aug2016 vid: 22 iid: 4 pid: 16919 pub: Wolters Kluwer India Pvt Ltd artinfo: ui: 117335294 117335294 117335294 10.4103/1319-3767.187605 117335294 ppf: 309 ppct: 7 formats: tig: atl: Sequential Versus Concomitant Therapy for Eradication of Helicobacter Pylori in Patients with Perforated Duodenal Ulcer: A Randomized Trial. aug: au: Das, Roby Sureshkumar, Sathasivam Sreenath, Gubbi S. Kate, Vikram affil: Department of Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India sug: subj: Disease Eradication Helicobacter Infections Therapy Gastroenterology Care Human Duodenal Ulcer Complications Randomized Controlled Trials Patient Compliance Health Care Costs Duodenal Ulcer Surgery Urease After Care Endoscopy Recurrence Tomography, X-Ray Computed Antibiotics Administration and Dosage ab: Objectives: Comparison of Helicobacter pylori eradication rates, side effects, compliance, cost, and ulcer recurrence of sequential therapy (ST) with that of concomitant therapy (CT) in patients with perforated duodenal ulcer following simple omental patch closure. Methods: Sixty-eight patients with perforated duodenal ulcer treated with simple closure and found to be H. pylori positive on three months follow-up were randomized to receive either ST or CT for H. pylori eradication. Urease test and Giemsa stain were used to assess for H. pylori eradication status. Follow-up endoscopies were done after 3 months, 6 months, and 1 year to evaluate the ulcer recurrence. Results: H. pylori eradication rates were similar in ST and CT groups on intention-to-treat (ITT) analysis (71.43% vs 81.80%, P = 0.40). Similar eradication rates were also found in per-protocol (PP) analysis (86.20% vs 90%, P = 0.71). Ulcer recurrence rate in ST groups and CT groups at 3 months (17.14% vs 6.06%, P = 0.26), 6 months (22.86% vs 9.09%, P = 0.19), and at 1 year (25.71 % vs 15.15%, P = 0.37) = follow-up was also similar by ITT analysis. Compliance and side effects to therapies were comparable between the groups. The most common side effects were diarrhoea and metallic taste in ST and CT groups, respectively. A complete course of ST costs Indian Rupees (INR) 570.00, whereas CT costs INR 1080.00. Conclusion: H. pylori eradication rates, side effects, compliance, cost, and ulcer recurrences were similar between the two groups. The ST was more economical compared with CT. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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