Extra-Gastrointestinal Manifestations of Inflammatory Bowel Disease May Be Less Common Than Previously Reported.
Background and Aims: Extra-intestinal manifestations are well recognized in inflammatory bowel disease (IBD). To what extent the commonly recognized extra-intestinal manifestations seen in IBD patients are attributable to IBD is, however, not clear due to the limited number of controlled studies pub...
| Publicado en: | Digestive Diseases & Sciences Vol. 61; no. 9; pp. 2619 - 2627 |
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| Autores principales: | , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Sep2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=117352540&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 117352540 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01632116 1VP jtl: Digestive Diseases & Sciences issn: 01632116 maglogo: N pubinfo: dt: Sep2016 vid: 61 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 117352540 117352540 NLM27193564 117352540 10.1007/s10620-016-4195-1 NLM27193564 117352540 ppf: 2619 ppct: 8 formats: tig: atl: Extra-Gastrointestinal Manifestations of Inflammatory Bowel Disease May Be Less Common Than Previously Reported. aug: au: Card, Timothy Langan, Sinéad Chu, Thomas Card, Timothy R Langan, Sinéad M Chu, Thomas P C affil: Faculty of Epidemiology and Population Health , London School of Hygiene and Tropical Medicine , London UK sug: subj: Arthritis Epidemiology Spondylitis, Ankylosing Epidemiology Erythema Nodosum Epidemiology Inflammatory Bowel Diseases Epidemiology Uveitis Epidemiology Cholangitis, Sclerosing Epidemiology Pyoderma Gangrenosum Epidemiology Psoriasis Epidemiology Odds Ratio Young Adult Prospective Studies Retrospective Design Male Female Adolescence Aged Child Myocardial Ischemia Epidemiology Rhinitis, Allergic, Seasonal Epidemiology Multiple Sclerosis Epidemiology Aged, 80 and Over Child, Preschool Infant, Newborn Middle Age Multivariate Analysis Adult Logistic Regression Case Control Studies Infant Human Adolescent: 13-18 years Aged: 65+ years Child: 6-12 years Aged, 80 & over Child, Preschool: 2-5 years Infant, Newborn: birth-1 month Middle Aged: 45-64 years Adult: 19-44 years Infant: 1-23 months Male Female ab: Background and Aims: Extra-intestinal manifestations are well recognized in inflammatory bowel disease (IBD). To what extent the commonly recognized extra-intestinal manifestations seen in IBD patients are attributable to IBD is, however, not clear due to the limited number of controlled studies published.Methods: We have conducted a study of these manifestations using electronic primary care records. We have identified extra-intestinal manifestations in IBD and non-IBD patients and derived odds ratios (ORs) using conditional logistic regression.Results: A total of 56,097 IBD patients (32.5 % Crohn's disease, 48.3 % ulcerative colitis (UC) and 19.2 % not classified) were matched to 280,382 non-IBD controls. We found records of pyoderma gangrenosum (OR = 29.24), erythema nodosum (OR = 5.95), primary sclerosing cholangitis (OR = 188.25), uveitis (OR = 2.81), ankylosing spondylitis (OR = 7.07), sacroiliitis (OR = 2.79) and non-rheumatoid inflammatory arthritides (OR = 2.66) to be associated with IBD. One or more of these was recorded in 8.1 % of IBD patients and 2.3 % of controls. Non-specific arthritides were present in many more patients, affecting 30 % of IBD patients and 23.8 % of controls overall. We also found weaker associations with a number of conditions not generally considered to be extra-intestinal manifestations including psoriasis, ischemic heart disease, multiple sclerosis and hay fever.Conclusion: Although "classical" extra-intestinal manifestations are strongly associated with IBD, most IBD patients remain unaffected. Arthropathies, perceived to be the commonest extra-intestinal manifestation, are not strongly associated with IBD, and the proportion of arthropathies attributable to IBD is likely to be small. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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