Different Vancomycin Immunoassays Contribute to the Variability in Vancomycin Trough Measurements in Neonates.
Substantial interassay variability (up to 20%) has been described for vancomycin immunoassays in adults, but the impact of neonatal matrix is difficult to quantify because of blood volume constraints in neonates. However, we provide circumstantial evidence for a similar extent of variability. Using...
| Publicado en: | BioMed Research International Vol. 2016; pp. 1 - 5 |
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| Autores principales: | , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
8/21/2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=117558019&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 117558019 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 8/21/2016 vid: 2016 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 117558019 117558019 117558019 10.1155/2016/1974972 117558019 ppf: 1 ppct: 4 formats: fmt: @attributes: type: P tig: atl: Different Vancomycin Immunoassays Contribute to the Variability in Vancomycin Trough Measurements in Neonates. aug: au: Samardzic, Janko Smits, Anne Spriet, Isabel Soldatovic, Ivan Atkinson, Andrew Bajcetic, Milica Van Den Anker, John N. Allegaert, Karel affil: Institute of Pharmacology, Clinical Pharmacology and Toxicology, Medical Faculty, University of Belgrade, 11000 Belgrade, Serbia sug: subj: Vancomycin Administration and Dosage Immunoassay Vancomycin Pharmacokinetics Human Infant, Newborn Chromatography, Liquid Methods Mass Spectrometry Methods Sepsis Drug Therapy Catheter-Related Infections Drug Therapy Academic Medical Centers Belgium Retrospective Design Descriptive Statistics T-Tests Mann-Whitney U Test Data Analysis Software P-Value Infant, Newborn: birth-1 month ab: Substantial interassay variability (up to 20%) has been described for vancomycin immunoassays in adults, but the impact of neonatal matrix is difficult to quantify because of blood volume constraints in neonates. However, we provide circumstantial evidence for a similar extent of variability. Using the same vancomycin dosing regimens and confirming similarity in clinical characteristics, vancomycin trough concentrations measured by PETINIA (2011-2012, n=400) were 20% lower and the mean difference was 1.93 mg/L compared to COBAS (2012–2014, n=352) measurements. The impact of vancomycin immunoassays in neonatal matrix was hereby suggested, supporting a switch to more advanced techniques (LC-MS/MS). pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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