A comprehensive compartmental model of blood glucose regulation for healthy and type 2 diabetic subjects.
We have expanded a former compartmental model of blood glucose regulation for healthy and type 2 diabetic subjects. The former model was a detailed physiological model which considered the interactions of three substances, glucose, insulin and glucagon on regulating the blood sugar. The main drawbac...
| Publicado en: | Medical & Biological Engineering & Computing Vol. 54; no. 9; pp. 1383 - 1399 |
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| Autores principales: | , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Sep2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=117576407&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 117576407 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01400118 PO0 jtl: Medical & Biological Engineering & Computing issn: 01400118 maglogo: N pubinfo: dt: Sep2016 vid: 54 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 117576407 117576407 NLM26493377 10.1007/s11517-015-1406-4 NLM26493377 117576407 ppf: 1383 ppct: 16 formats: fmt: @attributes: type: P tig: atl: A comprehensive compartmental model of blood glucose regulation for healthy and type 2 diabetic subjects. aug: au: Vahidi, O. Kwok, K. Gopaluni, R. Knop, F. Kwok, K E Gopaluni, R B Knop, F K affil: School of Chemical Engineering , Iran University of Science and Technology , Narmak, Tehran Iran sug: subj: Blood Glucose Metabolism Models, Biological Diabetes Mellitus, Type 2 Blood Reproducibility of Results Incretins Metabolism Glucose Tolerance Test Models, Theoretical Female Glucose Metabolism Clinical Trials Gastrointestinal System Metabolism Male Scales Female Male ab: We have expanded a former compartmental model of blood glucose regulation for healthy and type 2 diabetic subjects. The former model was a detailed physiological model which considered the interactions of three substances, glucose, insulin and glucagon on regulating the blood sugar. The main drawback of the former model was its restriction on the route of glucose entrance to the body which was limited to the intravenous glucose injection. To handle the oral glucose intake, we have added a model of glucose absorption in the gastrointestinal tract to the former model to address the resultant variations of blood glucose concentrations following an oral glucose intake. Another model representing the incretins production in the gastrointestinal tract along with their hormonal effects on boosting pancreatic insulin production is also added to the former model. We have used two sets of clinical data obtained during oral glucose tolerance test and isoglycemic intravenous glucose infusion test from both type 2 diabetic and healthy subjects to estimate the model parameters and to validate the model results. The estimation of model parameters is accomplished through solving a nonlinear optimization problem. The results show acceptable precision of the estimated model parameters and demonstrate the capability of the model in accurate prediction of the body response during the clinical studies. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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