Polyprenols of Ginkgo biloba Enhance Antibacterial Activity of Five Classes of Antibiotics.
Polyprenol (GBP) from Ginkgo biloba Leaves (GBL) is an important lipid with many bioactive effects. The effect of GBP on antibacterial properties of five antibiotics belonging to different classes was through analysis of inhibition halos, MIC, and FIC index. And we studied the time-killing curves an...
| Publicado en: | BioMed Research International Vol. 2016; pp. 1 - 9 |
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| Autores principales: | , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
8/23/2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=117619172&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 117619172 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 8/23/2016 vid: 2016 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 117619172 117619172 117619172 10.1155/2016/4191938 117619172 ppf: 1 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Polyprenols of Ginkgo biloba Enhance Antibacterial Activity of Five Classes of Antibiotics. aug: au: Tao, Ran Wang, Chengzhang Ye, Jianzhong Zhou, Hao Chen, Hongxia affil: Institute of Chemical Industry of Forest Products, CAF, 16 Suojin Wucun, Nanjing, Jiangsu 210042, China sug: subj: Ginkgo Biloba Antibiotics Administration and Dosage Bacteria Drug Effects Terpenes Administration and Dosage Staphylococcus Aureus Drug Effects Cell Culture Techniques Molecular Structure Gentamicins Administration and Dosage Biological Assay Calcium Drug Therapy, Combination Emulsions Ampicillin Administration and Dosage Ciprofloxacin Administration and Dosage Erythromycin Administration and Dosage Polymyxin B Administration and Dosage Microscopy, Electron Escherichia Coli Drug Effects Descriptive Statistics Analysis of Variance Post Hoc Analysis Data Analysis Software Particle Size Drug Synergism Funding Source ab: Polyprenol (GBP) from Ginkgo biloba Leaves (GBL) is an important lipid with many bioactive effects. The effect of GBP on antibacterial properties of five antibiotics belonging to different classes was through analysis of inhibition halos, MIC, and FIC index. And we studied the time-killing curves and Ca2+ mobilization assay in Staphylococcus aureus cells treated with GBP microemulsion and gentamicin sulfate under MIC/2 conditions. These results showed that the GBP microemulsion (average diameter 90.2 nm) combining with gentamicin sulfate had the highest enhancing antibacterial effect against Staphylococcus aureus, and the MIC value was 33.0 μg/mL. The increase of the antibacterial effect of tested antibiotics was positively correlated with the decrease of the average diameter of GBP microemulsion. Moreover, GBP microemulsion enhanced antibacterial effect and prolonged antibacterial time of GBP combining with gentamicin sulfate against Staphylococcus aureus. GBP microemulsion could enhance the ability of gentamicin inducing an increase in intracellular calcium concentrations to Staphylococcus aureus. GBP microemulsion could help some classes of antibiotics to inhibit or kill bacteria. This study supports the fact that GBP microemulsion obviously can not only reduce the dosage of some classes of antibiotics, but also reduce the frequency of the antibiotic use in vitro. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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